PMID- 11484302
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20071115
IS  - 1088-0224 (Print)
IS  - 1088-0224 (Linking)
VI  - 6
IP  - 20 Suppl
DP  - 2000 Nov
TI  - Overview of enoxaparin in the treatment of deep vein thrombosis.
PG  - S1026-33
AB  - Standard medical treatment for patients with acute venous thrombosis is 
      antithrombotic therapy. Following a historical overview of the evolution of 
      heparin therapy to include low-molecular weight heparin (LMWH), the 
      pharmacokinetic properties of enoxaparin are described. Therapeutic advantages of 
      LMWH over unfractionated heparin (UFH) are also discussed, including once- or 
      twice-daily subcutaneous dosing, reduced hospital stays, elimination of 
      therapeutic monitoring for most patients, and possibly less bone density loss. 
      Studies have demonstrated that enoxaparin is at least equivalent to UFH with 
      regard to efficacy and safety. Opportunities for future study include evaluation 
      of enoxaparin's efficacy for the prevention of deep vein thrombosis within 
      high-risk groups and for the treatment of thrombosis in such conditions as 
      pregnancy, cancer, obesity, and renal insufficiency, and in children.
FAU - Deitcher, S R
AU  - Deitcher SR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Manag Care
JT  - The American journal of managed care
JID - 9613960
RN  - 0 (Enoxaparin)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
MH  - Enoxaparin/pharmacokinetics/*therapeutic use
MH  - Fibrinolytic Agents/pharmacokinetics/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/pharmacokinetics/therapeutic use
MH  - Humans
MH  - Managed Care Programs
MH  - Meta-Analysis as Topic
MH  - Randomized Controlled Trials as Topic
MH  - Venous Thrombosis/*drug therapy/*prevention & control
RF  - 17
EDAT- 2001/08/04 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/08/04 10:00
PHST- 2001/08/04 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/08/04 10:00 [entrez]
AID - 752 [pii]
PST - ppublish
SO  - Am J Manag Care. 2000 Nov;6(20 Suppl):S1026-33.