PMID- 11485838
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190921
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 23
IP  - 4
DP  - 2001 Jul-Aug
TI  - Effect of prenatal ethanol exposure during the brain growth spurt of the guinea 
      pig.
PG  - 355-64
AB  - This study tested the hypothesis that prenatal ethanol exposure during the last 
      third of gestation, including the brain growth spurt (BGS), in the guinea pig 
      produces neurobehavioural teratogenicity, manifesting as brain growth restriction 
      and hyperactivity. Pregnant guinea pigs (term, about gestational day (GD) 68) 
      received oral administration of ethanol (2 g/kg maternal body weight per day on 
      GD 43 and/or GD 44 and then 4 g/kg maternal body weight per day from GD 45 to GD 
      62), isocaloric-sucrose/pair-feeding, or water. Maternal blood ethanol 
      concentration (BEC) on GD 57 or 58, at 1 h after the daily dose, was 340+/-76 
      mg/dl (n=8). Ethanol treatment decreased brain, cerebral cortical, hippocampal, 
      and cerebellar weights at GD 63 (P<0.05), and decreased brain and cerebral 
      cortical weights at postnatal day 10 (P<0.05), with no effect on body weight and 
      no apparent effect on spontaneous locomotor activity. The data demonstrate that, 
      in the guinea pig, prenatal ethanol exposure during the last third of gestation, 
      including the BGS, decreases brain weight that persists into postnatal life, 
      which is associated with growth restriction of the cerebral cortex. However, this 
      prenatal ethanol exposure regimen, including the BGS, does not increase 
      spontaneous locomotor activity in contrast to the persistent hyperactivity that 
      occurs after chronic ethanol exposure throughout gestation.
FAU - Byrnes, M L
AU  - Byrnes ML
AD  - Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen's 
      University, Kingston, Ontario, Canada K7L 3N6.
FAU - Reynolds, J N
AU  - Reynolds JN
FAU - Brien, J F
AU  - Brien JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Teratogens)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Brain/drug effects/*embryology/growth & development
MH  - Cerebral Cortex/*drug effects/growth & development
MH  - Energy Intake/drug effects
MH  - Ethanol/blood/*poisoning
MH  - Female
MH  - Gestational Age
MH  - Guinea Pigs
MH  - Motor Activity/drug effects
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Pregnancy, Animal/drug effects/*physiology
MH  - *Prenatal Exposure Delayed Effects
MH  - *Teratogens
EDAT- 2001/08/04 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/04 10:00
PHST- 2001/08/04 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/04 10:00 [entrez]
AID - S0892-0362(01)00150-7 [pii]
AID - 10.1016/s0892-0362(01)00150-7 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2001 Jul-Aug;23(4):355-64. doi: 
      10.1016/s0892-0362(01)00150-7.