PMID- 11486104
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20221207
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 32
IP  - 8
DP  - 2001 Aug
TI  - Difference in carotid artery wall structure between Swedish and French men at low 
      and high coronary risk.
PG  - 1775-9
AB  - BACKGROUND AND PURPOSE: We attempted to detect a group-specific north-south 
      difference in carotid artery intima-media thickness (IMT), a marker of subsequent 
      cardiovascular complication, by means of a case (high risk)-control (low risk) 
      study in French and Swedish men. METHODS: The selection of high-risk and low-risk 
      subjects was performed within the lower and upper percentiles of the Framingham 
      risk distribution of 2 samples of 1000 white, male auto workers (45 to 50 years 
      of age) in France (Renault) and Sweden (Volvo). In total, 299 men at low risk (79 
      French, 76 Swedish) and high risk (61 French, 83 Swedish), free from sustained 
      hypertension, definite hypercholesterolemia, and cardiovascular disease, were 
      included. Both common carotid arteries, by ultrasonography and central off-line 
      computerized analysis, provided measurements of far wall media thickness, lumen 
      diameter, and cross-sectional area IMT (CSA-IMT). RESULTS: As compared with 
      low-risk status, high-risk status was associated with higher IMT (P<0.001), 
      diameter (P<0.01), and CSA-IMT (P<0.001) in French men and higher CSA-IMT 
      (P<0.05) in Swedish men. IMT, diameter, and CSA-IMT were higher in Swedish than 
      in French men in the low-risk group (P<0.001) and in the high-risk group (P<0.01, 
      P<0.001, P<0.001). The multivariate analysis of the whole population showed that 
      IMT, diameter, and CSA-IMT were associated with risk status (P<0.01, P<0.01, 
      P<0.001) and geographic status (P<0.001). CONCLUSIONS: These findings show that 
      the geographic status influences carotid artery structure independent of 
      traditional cardiovascular risk factors and that this may affect the mortality 
      and morbidity gradient between Northern and Southern Europe.
FAU - Denarie, N
AU  - Denarie N
AD  - Centre de Medecine Preventive Cardiovasculaire, Hopital Broussais, Paris, France.
FAU - Simon, A
AU  - Simon A
FAU - Chironi, G
AU  - Chironi G
FAU - Gariepy, J
AU  - Gariepy J
FAU - Kumlin, L
AU  - Kumlin L
FAU - Massonneau, M
AU  - Massonneau M
FAU - Lanoiselee, C
AU  - Lanoiselee C
FAU - Dimberg, L
AU  - Dimberg L
FAU - Levenson, J
AU  - Levenson J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Age Distribution
MH  - Age Factors
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Carotid Artery, Common/anatomy & histology/*diagnostic imaging/physiology
MH  - Case-Control Studies
MH  - Cholesterol, HDL/blood
MH  - Coronary Disease/ethnology
MH  - France
MH  - Humans
MH  - Industry
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Occupations/statistics & numerical data
MH  - Risk Assessment
MH  - Sweden
MH  - Tunica Intima/anatomy & histology/*diagnostic imaging
MH  - Tunica Media/anatomy & histology/*diagnostic imaging
MH  - Ultrasonography
MH  - Vascular Patency/*physiology
MH  - White People
EDAT- 2001/08/04 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/08/04 10:00
PHST- 2001/08/04 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/08/04 10:00 [entrez]
AID - 10.1161/01.str.32.8.1775 [doi]
PST - ppublish
SO  - Stroke. 2001 Aug;32(8):1775-9. doi: 10.1161/01.str.32.8.1775.