PMID- 11486340
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20220311
IS  - 1073-8584 (Print)
IS  - 1073-8584 (Linking)
VI  - 7
IP  - 1
DP  - 2001 Feb
TI  - Neurotrophic factors: important regulators of nociceptive function.
PG  - 13-7
AB  - Neurotrophic factors have an established developmental role in regulating the 
      survival and specification of sensory neurons. However, these factors continue to 
      exert an important influence on sensory neurons throughout the postnatal period 
      and into adult life. In adulthood, approximately one-half of nociceptors are 
      dependent on nerve growth factor (NGF) for trophic support, whereas the other 
      half are sensitive to glial cell line-derived neurotrophic factor (GDNF). It is 
      now known that many chronic pain states are maintained by widespread changes in 
      the anatomy, neurochemistry, and function of the sensory nervous system both at 
      the level of the primary sensory neuron and the dorsal horn of the spinal cord. 
      Trophic factors appear to orchestrate many of these dynamic changes. This review 
      highlights some of the key roles played by these molecules and in particular the 
      role of NGF in the peripheral sensitization of nociceptors and brain-derived 
      neurotrophic factor (BDNF) as a central pain modulator.
FAU - Bennett, D L
AU  - Bennett DL
AD  - Dept. Physiology, St Thomas' Hospital Medical School, Lambeth Palace Rd., London, 
      SE1 7EH, UK. david.bennett@kcl.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/physiology/therapeutic use
MH  - Humans
MH  - Inflammation
MH  - Models, Neurological
MH  - Nerve Growth Factor/*physiology/therapeutic use
MH  - Nociceptors/*physiology
MH  - Pain/drug therapy/*physiopathology
RF  - 25
EDAT- 2001/08/07 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/08/07 10:00
PHST- 2001/08/07 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/08/07 10:00 [entrez]
AID - 10.1177/107385840100700105 [doi]
PST - ppublish
SO  - Neuroscientist. 2001 Feb;7(1):13-7. doi: 10.1177/107385840100700105.