PMID- 11486651
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20191105
IS  - 1127-0020 (Print)
IS  - 1127-0020 (Linking)
VI  - 5
IP  - 2
DP  - 2001 Jun
TI  - Unrelated donor hematopoietic transplantation.
PG  - 100-34
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of 
      choice for a range of malignant and non-malignant diseases. Unfortunately, fewer 
      than 30% of patients have a human leukocyte antigen (HLA)-matched sibling. 
      Advances in our understanding of the HLA system and the development of large 
      international donor registries are supporting the increasing use of unrelated 
      donors as an alternative source of stem cells. Unrelated donor transplantation, 
      however, is still associated with higher complication rates than in HLA-identical 
      sibling donor transplants. Improvements in graft-vs.-host disease prevention and 
      treatment, new conditioning regimens and better donor selection will likely 
      expand the indications of unrelated donor HSCT in the next decade.
FAU - de Lima, M
AU  - de Lima M
AD  - Department of Blood and Marrow Transplantation, University of Texas, MD Anderson 
      Cancer Center, 1515 Holcombe Blvd, Box 423, Houston 77030-4009, Texas, USA.
FAU - Champlin, R
AU  - Champlin R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Rev Clin Exp Hematol
JT  - Reviews in clinical and experimental hematology
JID - 9815344
SB  - IM
MH  - Graft vs Host Disease/drug therapy/etiology/prevention & control
MH  - Hematopoietic Stem Cell Transplantation/methods/*standards
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Tissue Donors
MH  - Transplantation, Homologous/methods/standards
MH  - Treatment Outcome
RF  - 129
EDAT- 2001/08/07 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/08/07 10:00
PHST- 2001/08/07 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/08/07 10:00 [entrez]
AID - 10.1046/j.1468-0734.2001.00035.x [doi]
PST - ppublish
SO  - Rev Clin Exp Hematol. 2001 Jun;5(2):100-34. doi: 
      10.1046/j.1468-0734.2001.00035.x.