PMID- 11486656
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20191105
IS  - 1127-0020 (Print)
IS  - 1127-0020 (Linking)
VI  - 5
IP  - 2
DP  - 2001 Jun
TI  - Results of unrelated umbilical cord blood hematopoietic stem cell 
      transplantation.
PG  - 87-99
AB  - The number of umbilical cord blood transplants is increasing worldwide. The 
      purpose of Eurocord is to evaluate the results and to compare the outcome of 
      umbilical cord blood transplants with allogeneic bone marrow transplants. Data 
      have been reported to Eurocord by multiple transplant centers. Close links have 
      been established with the cord blood banks through Netcord. Bone marrow 
      transplant data have been provided by transplant centers and also through the 
      European Group for Blood and Marrow Transplantation (EBMT) and International Bone 
      Marrow Transplant Registries (IBMTR). Eurocord has analyzed the outcome of 
      unrelated umbilical cord blood transplants from 121 transplant centers and 29 
      countries. The results showed that survival with unrelated mismatched umbilical 
      cord blood transplants was comparable to that with unrelated bone marrow 
      transplants. Engraftment with cord blood was delayed, resulting in an increased 
      incidence of early transplant complications. The incidence of acute and chronic 
      graft-vs.-host disease was reduced with cord blood grafts even in human leukocyte 
      antigen (HLA)-mismatched transplants and in adults. In patients with leukemia, 
      the rate of relapse was similar to the rate of relapse after bone marrow 
      transplant. The overall event-free survival with umbilical cord blood 
      transplantation was not statistically different when compared to bone marrow 
      transplants. This large registry study confirms the potential benefit of using 
      umbilical cord blood hematopoietic stem cells for allogeneic transplants.
FAU - Gluckman, E
AU  - Gluckman E
AD  - Eurocord Hematology Bone Marrow Transplant and Biostatistics Departments, 
      Hospital Saint Louis, Paris, France. eliane.gluckman@sls.aphop-paris.fr
FAU - Rocha, V
AU  - Rocha V
FAU - Chevret, S
AU  - Chevret S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Italy
TA  - Rev Clin Exp Hematol
JT  - Reviews in clinical and experimental hematology
JID - 9815344
SB  - IM
MH  - Fetal Blood/*cytology
MH  - Hematopoietic Stem Cell Transplantation/methods/*standards
MH  - Histocompatibility
MH  - Humans
MH  - Transplantation, Homologous/standards
MH  - Treatment Outcome
RF  - 21
EDAT- 2001/08/07 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/08/07 10:00
PHST- 2001/08/07 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/08/07 10:00 [entrez]
AID - 10.1046/j.1468-0734.2001.00034.x [doi]
PST - ppublish
SO  - Rev Clin Exp Hematol. 2001 Jun;5(2):87-99. doi: 10.1046/j.1468-0734.2001.00034.x.