PMID- 11487476
OWN - NLM
STAT- MEDLINE
DCOM- 20011213
LR  - 20190901
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 6
DP  - 2001 Aug 1
TI  - Genetic organization of the human MHC class III region.
PG  - D914-26
AB  - The human major histocompatibility complex (MHC), or human leukocyte antigen 
      (HLA) region, encompasses over 4 Mb of DNA on the short arm of chromosome 6 and 
      is traditionally divided into the class I, class II and class III regions. The 
      MHC has now been entirely sequenced and ~220 genes have been defined of which ~62 
      are in the class III region. It is becoming clear that many of the latter encode 
      proteins that are likely to be involved in the immune and inflammatory responses. 
      The MHC is known to contribute to a large number of immune-related disorders 
      including insulin dependent diabetes mellitus, rheumatoid arthritis, common 
      variable immunodeficiency and IgA deficiency and there is growing evidence that 
      genes within the class III region are important in determining susceptibility to 
      many of these complex conditions. Genes in the class III region have also been 
      implicated in a number of non-immune-related diseases such as congenital adrenal 
      hyperplasia and sialidosis. Now that the full gene content of the class III 
      region is known the stage is set for the identification and characterisation of 
      candidate disease genes, which will allow greater understanding of the causes of 
      many MHC-linked diseases and thus aid the development of improved treatments.
FAU - Milner, C M
AU  - Milner CM
AD  - MRC Immunochemistry Unit, University of Oxford, UK. cmilner@molbiol.ox.ac.uk
FAU - Campbell, R D
AU  - Campbell RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20010801
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
SB  - IM
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immune System Diseases/genetics
MH  - *Major Histocompatibility Complex
RF  - 127
EDAT- 2001/08/07 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/07 10:00
PHST- 2001/08/07 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/07 10:00 [entrez]
AID - 10.2741/milner [doi]
PST - epublish
SO  - Front Biosci. 2001 Aug 1;6:D914-26. doi: 10.2741/milner.