PMID- 11487776
OWN - NLM
STAT- MEDLINE
DCOM- 20030603
LR  - 20151119
IS  - 1117-1936 (Print)
VI  - 8
IP  - 1
DP  - 2001 Mar
TI  - Evaluation of nucleolar organizer regions in tumours of the jaw bones.
PG  - 7-11
AB  - Nucleolar organizer regions [NORS] are loops of DNA that transcribe to ribosomal 
      RNA. They can be visualized as intranuclear black dots by histochemical staining 
      with a colloid silver solution. Silver stained nucleolar proteins (AgNORs) were 
      counted in a variety of jaw bone tumours. In osteosarcomas, the number of AgNORs 
      was also quantified before and after chemotherapy. Malignant bone tumour cells 
      possessed more than five small AgNORs (5.54 +/- 0.44). Nuclei of benign jaw bone 
      tumour cells had less than three (2. 97 +/-0.61). A significant difference in the 
      number of AgNORs between osteosarcoma before chemotherapy (5.76 +/- 0.50) and 
      after chemotherapy (3.89 +/- 1.65) was observed. (P < 0.05). The number ofAgNORs 
      in recurrent osteosarcoma, recurrent ameloblastic carcinoma and recurrent 
      chondrosarcoma was much higher than in their respective primary lesion but 
      without statistical significant difference. The results of the present study 
      indicate that the AGNOR count might help in determining malignancy, evaluating 
      the effect of chemotherapy, and deciding the prognosis.
FAU - Afolabi, O C
AU  - Afolabi OC
AD  - Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
FAU - Odukoya, O
AU  - Odukoya O
FAU - Arole, G
AU  - Arole G
FAU - Banjo, A F
AU  - Banjo AF
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Postgrad Med J
JT  - The Nigerian postgraduate medical journal
JID - 9613595
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Ameloblastoma/genetics/pathology
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - Biomarkers, Tumor/*genetics
MH  - Case-Control Studies
MH  - Chondrosarcoma/genetics/pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Jaw Neoplasms/drug therapy/*genetics/pathology
MH  - Nucleolus Organizer Region/drug effects/*pathology
MH  - Osteosarcoma/drug therapy/genetics/pathology
MH  - Silver Staining
EDAT- 2001/08/07 10:00
MHDA- 2003/06/05 05:00
CRDT- 2001/08/07 10:00
PHST- 2001/08/07 10:00 [pubmed]
PHST- 2003/06/05 05:00 [medline]
PHST- 2001/08/07 10:00 [entrez]
PST - ppublish
SO  - Niger Postgrad Med J. 2001 Mar;8(1):7-11.