PMID- 11488333
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 17
IP  - 5
DP  - 2001 May
TI  - Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia.
PG  - 962-8
AB  - Chronic eosinophilic pneumonia (CEP) is characterized by chronic or recurrent 
      pulmonary infiltrates with eosinophils, but the precise mechanism of eosinophil 
      accumulation has not been fully elucidated. Eotaxin is one of the CC chemokines 
      that selectively recruits eosinophils and contributes to the pathogenesis of 
      allergic airway diseases including asthma, but its roles in pathogenesis of CEP 
      have not been fully elucidated. The authors measured concentrations of eotaxin 
      and other CC chemokines, monocyte chemoattractant protein-1 (MCP-1), regulated on 
      activation, normal T-cell expressed and secreted, macrophage inflammatory 
      protein-1alpha, and the eosinophil activating Th2 cytokine interleukin (IL)-5 in 
      bronchoalveolar lavage (BAL) fluid from CEP patients (n=11), and compared these 
      concentrations with those from control subjects (n = 6). The eotaxin (904 +/- 203 
      versus 29 +/- 7 pg x mL(-1), p = 0.0001), MCP-1 (194 +/- 57 versus 15 +/- 2 pg x 
      mL(-1), p < 0.05), and IL-5 (7.8 +/- 2.0 versus 2.7 +/- 0.6 pg x mL(-1), p < 
      0.05) levels were significantly higher for cases with CEP in comparison to those 
      serving as controls. Proportions of eosinophil and lymphocyte counts were greater 
      in BAL fluid from CEP patients. Eotaxin and IL-5 levels correlated with the 
      proportion of eosinophils in BAL fluid from CEP patients. MCP-1 correlated with 
      the relative lymphocyte numbers. In short, eotaxin, interleukin-5, and monocyte 
      chemoattractant protein-1 levels were higher in the BAL fluid of CEP patients and 
      these levels may contribute to eosinophil and lymphocyte recruitment and 
      activation in the airways as found with this disorder.
FAU - Tateno, H
AU  - Tateno H
AD  - Dept of Medicine, School of Medicine, Keio University, Tokyo, Japan.
FAU - Nakamura, H
AU  - Nakamura H
FAU - Minematsu, N
AU  - Minematsu N
FAU - Amakawa, K
AU  - Amakawa K
FAU - Terashima, T
AU  - Terashima T
FAU - Fujishima, S
AU  - Fujishima S
FAU - Luster, A D
AU  - Luster AD
FAU - Lilly, C M
AU  - Lilly CM
FAU - Yamaguchi, K
AU  - Yamaguchi K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (CCL11 protein, human)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines, CC)
RN  - 0 (Interleukin-5)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Chemokine CCL11
MH  - Chemokine CCL2/*metabolism
MH  - Chemokines, CC/*metabolism
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Interleukin-5/metabolism
MH  - Leukocyte Count
MH  - Lymphocyte Activation/immunology
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Eosinophilia/*immunology
EDAT- 2001/08/08 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/08 10:00
PHST- 2001/08/08 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/08 10:00 [entrez]
AID - 10.1183/09031936.01.17509620 [doi]
PST - ppublish
SO  - Eur Respir J. 2001 May;17(5):962-8. doi: 10.1183/09031936.01.17509620.