PMID- 11488366
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20221207
IS  - 0160-6689 (Print)
IS  - 0160-6689 (Linking)
VI  - 62
IP  - 7
DP  - 2001 Jul
TI  - Adherence assessments and the use of depot antipsychotics in patients with 
      schizophrenia.
PG  - 545-51
AB  - BACKGROUND: Antipsychotic medications significantly ameliorate the symptoms of 
      schizophrenia, but patients are often noncompliant with these medications. 
      Research evidence supports the use of depot antipsychotics in noncompliant 
      patients. METHOD: Between January 9, 1991, and December 19, 1995, 1307 veterans 
      with schizophrenia or schizoaffective disorder (ICD-9) were enrolled in a study 
      of enhanced psychosocial programming at 14 Veterans Administration Medical 
      Centers. All had a history of high inpatient use. At enrollment, clinicians 
      listed patient medications, rated patient compliance, and completed a Brief 
      Psychiatric Rating Scale (BPRS) and Global Assessment of Functioning (GAF). 
      Patients reported medication side effects. We describe depot antipsychotic use 
      among these patients and examine the relationship between depot use, assessed 
      compliance, and patient characteristics. RESULTS: At enrollment, 18% of patients 
      in this cohort were receiving depot antipsychotics; however, clinicians reported 
      that 49% had been noncompliant with medication in the past year. Depot use varied 
      significantly with treatment site; African Americans were more likely to receive 
      depot antipsychotics and less likely to receive atypical antipsychotics than 
      white patients. Patients on depot and oral agents had similar levels of 
      psychiatric symptoms, but patients on depot antipsychotics were more likely to 
      receive high doses and complain of side effects. CONCLUSION: Clinicians 
      prescribed depot antipsychotics relatively infrequently, despite high rates of 
      noncompliance and high levels of inpatient use. Variation in use with treatment 
      site and ethnic group suggests barriers to implementing research-based 
      recommendations for depot use in noncompliant patients. Quality improvement 
      programs should consider facilitating the appropriate use of depots.
FAU - Valenstein, M
AU  - Valenstein M
AD  - Department of Veterans Affairs, Serious Mental Illness Treatment Evaluation, and 
      Research Center, Ann Arbor, Mich 48113-0170, USA.
FAU - Copeland, L A
AU  - Copeland LA
FAU - Owen, R
AU  - Owen R
FAU - Blow, F C
AU  - Blow FC
FAU - Visnic, S
AU  - Visnic S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Delayed-Action Preparations)
SB  - IM
MH  - Adult
MH  - Black or African American/statistics & numerical data
MH  - Age Factors
MH  - Aged
MH  - Antipsychotic Agents/administration & dosage/*therapeutic use
MH  - Delayed-Action Preparations
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Hospitals, Veterans/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Compliance/psychology/statistics & numerical data
MH  - Practice Patterns, Physicians'
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychotic Disorders/drug therapy/psychology
MH  - Schizophrenia/diagnosis/*drug therapy
MH  - Schizophrenic Psychology
MH  - Treatment Refusal/psychology/statistics & numerical data
MH  - White People/statistics & numerical data
EDAT- 2001/08/08 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/08/08 10:00
PHST- 2001/08/08 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/08/08 10:00 [entrez]
AID - 10.4088/jcp.v62n07a08 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2001 Jul;62(7):545-51. doi: 10.4088/jcp.v62n07a08.