PMID- 11488714
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20190921
IS  - 0004-8380 (Print)
IS  - 0004-8380 (Linking)
VI  - 42
IP  - 3
DP  - 2001 Aug
TI  - A case of severe actinic prurigo successfully treated with thalidomide.
PG  - 192-5
AB  - Actinic prurigo is an uncommon and usually persistent idiopathic photodermatosis 
      with typical human leukocyte antigen (HLA) associations (HLA-DR4, particularly 
      subtypes DRB1*0407 and DRB1*0401). Although its mechanism of action is not 
      clearly understood, thalidomide has been shown to be particularly efficacious in 
      treating actinic prurigo, among other conditions. A 31-year-old Australian woman 
      who had suffered actinic prurigo for most of her life was treated with two 
      courses of thalidomide (50-100 mg nocte) over consecutive summers. Remission was 
      observed after cessation of the second course of thalidomide and had continued 4 
      years later. Abnormalities in the cutaneous response to ultraviolet radiation at 
      the time of diagnosis, detected by monochromator phototesting, reverted to normal 
      following treatment.
FAU - Ng, J C
AU  - Ng JC
AD  - The University of Melbourne, Department of Medicine (Dermatology), St Vincent's 
      Hospital, Melbourne, Victoria, Australia.
FAU - Foley, P A
AU  - Foley PA
FAU - Crouch, R B
AU  - Crouch RB
FAU - Baker, C S
AU  - Baker CS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Australas J Dermatol
JT  - The Australasian journal of dermatology
JID - 0135232
RN  - 0 (Dermatologic Agents)
RN  - 4Z8R6ORS6L (Thalidomide)
SB  - IM
MH  - Adult
MH  - Arm
MH  - Dermatitis, Photoallergic/*diagnosis/drug therapy/pathology
MH  - Dermatologic Agents/*therapeutic use
MH  - Diagnosis, Differential
MH  - Facial Dermatoses/*diagnosis/drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Prurigo/*diagnosis/drug therapy/pathology
MH  - Thalidomide/*therapeutic use
RF  - 17
EDAT- 2001/08/08 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/08/08 10:00
PHST- 2001/08/08 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/08/08 10:00 [entrez]
AID - ajd513 [pii]
AID - 10.1046/j.1440-0960.2001.00513.x [doi]
PST - ppublish
SO  - Australas J Dermatol. 2001 Aug;42(3):192-5. doi: 
      10.1046/j.1440-0960.2001.00513.x.