PMID- 11488957
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 14
IP  - 1
DP  - 2001 Jul
TI  - BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of 
      neonatal ventral hippocampal damage and antipsychotic drugs.
PG  - 135-44
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in development, 
      synapse remodelling and responses to stress and injury. Its abnormal expression 
      has been implicated in schizophrenia, a neuropsychiatric disorder in which 
      abnormal neural development of the hippocampus and prefrontal cortex has been 
      postulated. To clarify the effects of antipsychotic drugs used in the therapy of 
      schizophrenia on BDNF mRNA, we studied its expression in rats treated with 
      clozapine and haloperidol and in rats with neonatal lesions of the ventral 
      hippocampus, used as an animal model of schizophrenia. Both antipsychotic drugs 
      reduced BDNF expression in the hippocampus of control rats, but did not 
      significantly lower its expression in the prefrontal cortex. The neonatal 
      hippocampal lesion itself suppressed BDNF mRNA expression in the dentate gyrus 
      and tended to reduce its expression in the prefrontal cortex. These results 
      indicate that, unlike antidepressants, antipsychotics down-regulate BDNF mRNA, 
      and suggest that their therapeutic properties are not mediated by stimulation of 
      this neurotrophin. To the extent that the lesioned rat models some 
      pathophysiological aspects of schizophrenia, our data suggest that a 
      neurodevelopmental insult might suppress expression of the neurotrophin in 
      certain brain regions.
FAU - Lipska, B K
AU  - Lipska BK
AD  - Clinical Brain Disorders Branch, Intramural Research Program, National Institute 
      of Mental Health, Bethesda, MD, 20892-1385 USA. lipskab@intra.nimh.gov
FAU - Khaing, Z Z
AU  - Khaing ZZ
FAU - Weickert, C S
AU  - Weickert CS
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - J60AR2IKIC (Clozapine)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*growth & development/metabolism
MH  - Antipsychotic Agents/*pharmacology
MH  - Axotomy
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Clozapine/pharmacology
MH  - Down-Regulation/drug effects/physiology
MH  - Gene Expression Regulation, Developmental/drug effects/physiology
MH  - Haloperidol/pharmacology
MH  - Hippocampus/drug effects/*growth & development/surgery
MH  - Neurons/drug effects/*metabolism
MH  - Prefrontal Cortex/drug effects/*growth & development/metabolism
MH  - RNA, Messenger/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schizophrenia/metabolism/pathology/physiopathology
EDAT- 2001/08/08 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/08/08 10:00
PHST- 2001/08/08 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/08/08 10:00 [entrez]
AID - ejn1633 [pii]
AID - 10.1046/j.1460-9568.2001.01633.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2001 Jul;14(1):135-44. doi: 10.1046/j.1460-9568.2001.01633.x.