PMID- 11495150
OWN - NLM
STAT- MEDLINE
DCOM- 20011205
LR  - 20081121
IS  - 0941-1291 (Print)
IS  - 0941-1291 (Linking)
VI  - 31
IP  - 7
DP  - 2001
TI  - Increased plasma concentration of adrenomedullin during and after major surgery.
PG  - 575-9
AB  - Adrenomedullin (AM), a novel vasodilatory peptide, appears to participate in the 
      regulation of circulation. Recent studies have reported a relationship between AM 
      and cytokine. The present study was performed to determine whether major surgery, 
      which is accompanied by an altered cytokine production, affects the concentration 
      of plasma AM. Eighteen patients undergoing major upper abdominal and 
      thoracoabdominal surgery were thus studied. Arterial blood samples were obtained 
      before anesthetic induction (PRE), 2h after a surgical incision was made (2H), at 
      the end of surgery (END), at postoperative day 1 (1POD), and at 3POD. The 
      concentrations of plasma AM and serum interleukin (IL)-6 were measured. The 
      levels of plasma AM were found to be significantly higher at END (P < 0.001), 
      1POD (P < 0.0001), and 3POD (P < 0.05) compared with PRE. A significant 
      correlation was found between the concentrations of serum IL-6 and plasma AM (r = 
      0.59, n = 18, P < 0.01). These results suggest that major surgical stress might 
      thus increase the plasma AM concentration, and such an increase may be related to 
      cytokine induction.
FAU - Fujioka, S
AU  - Fujioka S
AD  - Department of Anesthesiology, School of Medicine, Teikyo University, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (Interleukin-6)
RN  - 0 (Peptides)
RN  - 0 (Vasodilator Agents)
RN  - 148498-78-6 (Adrenomedullin)
SB  - IM
MH  - Abdomen/*surgery
MH  - Adrenomedullin
MH  - Aged
MH  - Central Venous Pressure
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Peptides/*blood
MH  - Postoperative Period
MH  - Stress, Physiological/*blood/etiology
MH  - Thoracic Surgical Procedures/*adverse effects
MH  - Time Factors
MH  - Vasodilator Agents/*blood
EDAT- 2001/08/10 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/10 10:00
PHST- 2001/08/10 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/10 10:00 [entrez]
AID - 10.1007/s005950170089 [pii]
AID - 10.1007/s005950170089 [doi]
PST - ppublish
SO  - Surg Today. 2001;31(7):575-9. doi: 10.1007/s005950170089.