PMID- 11495293
OWN - NLM
STAT- MEDLINE
DCOM- 20020123
LR  - 20161021
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 19
IP  - 1
DP  - 2001 Mar
TI  - Correlation of total and specific serum immunoglobulin E levels with the severity 
      of chronic sinusitis in children.
PG  - 1-6
AB  - Chronic sinusitis is frequently associated with allergy and asthma. Previous 
      studies have shown that serum immunoglobulin E (IgE) levels correlate with 
      allergy and asthma in adults. Because the role of allergic inflammation in the 
      severity of chronic sinusitis remains controversial in children, we set out to 
      determine whether a correlation exists between serum levels of total and specific 
      IgE and the severity of chronic sinusitis in children. Forty-four children with 
      chronic sinusitis were enrolled in the study. Computed tomographic scans were 
      reviewed and scored for the severity of sinusitis. All children were 
      mite-sensitive. Serum samples were assayed for total IgE and specific IgE 
      antibodies to mite allergen using a fluoroimmunoassay. Fourteen subjects had 
      extensive sinus disease. There was no significant difference in the average of 
      total and specific IgE between the subjects with extensive and limited disease (p 
      = 0.562 and 0.755, respectively). Thirty-four subjects were diagnosed with 
      asthma. The subjects with extensive sinus disease had a higher prevalence of 
      moderate to severe asthma than the subjects with limited disease (p = 0.006), but 
      there was no significant difference in the average of total and specific IgE 
      between the subjects with different severities of asthma. (p = 0.833 and 0.425, 
      respectively). The data suggests that levels of total or specific IgE do not 
      correlate with severity of chronic sinusitis in children. Nonetheless, the 
      severity of chronic sinusitis and asthma correlate well with each other 
      irrespective of total and specific IgE.
FAU - Lin, Y L
AU  - Lin YL
AD  - Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Huang, J L
AU  - Huang JL
FAU - Chen, L C
AU  - Chen LC
FAU - Wang, C R
AU  - Wang CR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Antibody Specificity/*immunology
MH  - Blood Proteins/analysis/immunology
MH  - Child
MH  - Child Welfare
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Eosinophil Granule Proteins
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/*immunology
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Ribonucleases
MH  - Severity of Illness Index
MH  - Sinusitis/*blood/*epidemiology/*immunology
MH  - Statistics as Topic
MH  - Taiwan/epidemiology
EDAT- 2001/08/10 10:00
MHDA- 2002/01/24 10:01
CRDT- 2001/08/10 10:00
PHST- 2001/08/10 10:00 [pubmed]
PHST- 2002/01/24 10:01 [medline]
PHST- 2001/08/10 10:00 [entrez]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2001 Mar;19(1):1-6.