PMID- 1149531
OWN - NLM
STAT- MEDLINE
DCOM- 19751021
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 68
IP  - 1
DP  - 1975 Jul
TI  - Diastolic time intervals in ischemic and hypertensive heart disease: A comparison 
      of isovolumic relaxation time and rapid filling time with systolic time 
      intervals.
PG  - 56-61
AB  - Isovolumic relaxation time (IVRT) and rapid filling time (RFT) were used to 
      evaluate elasticity and compliance in 11 control subjects (Group 1), in nine 
      patients with angina (Group 2), in 11 with hypertensive heasrt disease (Group 3), 
      and in ten patients with healed myocardial infarction (Group 4). Pre-ejection 
      period (PEP), pre-ejection period index (PEPI), left ventricular ejection time 
      (LVET), left ventricular ejection time index(LVETI) and PEP/LVET ratio were all 
      derived from simultaneous recordings of phonocardiograms, ECGs, apexcardiograms, 
      and external carotid arterial pulses. No patients were in congestive heart 
      failure and none were receiving medication. LVET and LVETI were the same in 
      control patient groups; PEP was slightly increased in patients with healed 
      myocardial infarctions (p smaller than 0.05); and PEPI was prolonged in the 
      patients with angina (p = 0.001). THE PEP/LVET ratio too was different from the 
      control group in patients with angina and hypertension (Groups 2 and 3-p smaller 
      than 0.02 and smaller than 0.05 respectively). The diastolic time intervals were 
      significantly altered in that the IVRT was prolonged in angina patients (113.4 
      equals or minus 28.3 msec), compared to control patients (85.7) equal or minus 
      18.4 msec). It was found that in 6 out of 9 patients with angina, this interval 
      exceeded the highest normal value (108 msec), but that in only one out 11 
      patients with HCVD and in three out of ten with healed infarctions, was the 
      interval prolonged. RFT was increased in HCVD (113.8 equals or minus 18.8 msec) 
      and in healed myocardial infarction (123.8 equals or minus 30.0 msec) patients, 
      compared to the control group (94.5 equals or minus 12.8 msec). Diastolic time 
      intervals reflecting disorders in elasticity and compliance may occur in 
      conjunction with alterations in systolic time intervals.
FAU - D'Angelo, R
AU  - D'Angelo R
FAU - Shah, N
AU  - Shah N
FAU - Rubler, S
AU  - Rubler S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angina Pectoris/physiopathology
MH  - Blood Pressure
MH  - Cardiac Output
MH  - Coronary Disease/*physiopathology
MH  - Electrocardiography
MH  - Female
MH  - Heart/*physiopathology
MH  - Heart Rate
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Hypertension/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardial Infarction/physiopathology
EDAT- 1975/07/01 00:00
MHDA- 1975/07/01 00:01
CRDT- 1975/07/01 00:00
PHST- 1975/07/01 00:00 [pubmed]
PHST- 1975/07/01 00:01 [medline]
PHST- 1975/07/01 00:00 [entrez]
AID - S0012-3692(15)36561-2 [pii]
AID - 10.1378/chest.68.1.56 [doi]
PST - ppublish
SO  - Chest. 1975 Jul;68(1):56-61. doi: 10.1378/chest.68.1.56.