PMID- 11496624
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20240328
IS  - 0008-4263 (Print)
IS  - 1920-7476 (Electronic)
IS  - 0008-4263 (Linking)
VI  - 92
IP  - 3
DP  - 2001 May-Jun
TI  - Comparing benefits and risks of immunization.
PG  - 173-7
AB  - BACKGROUND: This paper uses a straightforward method of quantifying the benefits 
      and risks of immunization, illustrated by universal immunization programs in 
      British Columbia against invasive Haemophilus influenzae type b disease (Hib), 
      measles, rubella, and paralytic poliomyelitis. METHODS: Data were extracted from 
      provincial communicable disease and vaccine adverse event surveillance systems. 
      Average disease incidence was compared before and after implementing universal 
      immunization programs. Estimates of prevented deaths and serious disease 
      complications were calculated and compared with expected numbers of serious 
      vaccine-associated adverse events (VAAEs). RESULTS: Average incidence of reported 
      cases decreased 90 to 100% over a 5-year period after implementing universal 
      programs. These benefits were sustained or strengthened over time. Rates of 
      reported serious VAAEs were low. DISCUSSION: The remarkable success of 
      immunization has created a paradox. Despite a low absolute risk of serious VAAEs, 
      the relative risk of some VAAEs can exceed risk of disease in the province.
FAU - Bigham, M
AU  - Bigham M
AD  - BC Centre for Disease Control, 655 W 12th Avenue, Vancouver, BC V5Z 4R4. 
      mark.bigham@bccdc.hnet.bc.ca
FAU - Hoefer, M
AU  - Hoefer M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
RN  - 0 (Vaccines)
SB  - IM
MH  - British Columbia
MH  - Child
MH  - Child, Preschool
MH  - Haemophilus influenzae type b/virology
MH  - Humans
MH  - *Immunization Programs
MH  - Incidence
MH  - Measles/epidemiology/*prevention & control
MH  - Meningitis, Haemophilus/epidemiology/*prevention & control
MH  - Poliomyelitis/epidemiology/*prevention & control
MH  - Risk
MH  - Rubella/epidemiology/*prevention & control
MH  - Vaccines/*adverse effects/*therapeutic use
PMC - PMC6979848
EDAT- 2001/08/11 10:00
MHDA- 2001/08/31 10:01
PMCR- 2002/05/01
CRDT- 2001/08/11 10:00
PHST- 2001/08/11 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/08/11 10:00 [entrez]
PHST- 2002/05/01 00:00 [pmc-release]
AID - BF03404299 [pii]
AID - 10.1007/BF03404299 [doi]
PST - ppublish
SO  - Can J Public Health. 2001 May-Jun;92(3):173-7. doi: 10.1007/BF03404299.