PMID- 11498748
OWN - NLM
STAT- MEDLINE
DCOM- 20011213
LR  - 20061115
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 28
IP  - 1
DP  - 2001 Jul
TI  - Correlation between HHV-6 infection and skin rash after allogeneic bone marrow 
      transplantation.
PG  - 77-81
AB  - We investigated whether a causal relationship exists between human herpesvirus 6 
      (HHV-6) and skin rash resembling acute graft-versus-host disease (GVHD) following 
      bone marrow transplantation (BMT). Isolation of HHV-6 was used to monitor active 
      HHV-6 infection in this study. We analyzed 25 episodes of skin rash in 22 
      recipients. All recipients were seropositive for HHV-6 before BMT. The onset of 
      skin rash started prior to 30 days post transplantation (group A) in 15 of 25 
      cases, but after that (group B) in the remaining 10 cases. Twenty-five skin 
      tissue samples were obtained from 22 recipients. The HHV-6 genome was detected in 
      four of 15 skin samples from group A, but not detected in those from group B. 
      HHV-6 was isolated from 11 of 22 recipients around 2 to 3 weeks after BMT (range 
      14 to 28 days after BMT). HHV-6 was isolated at a time between 10 days before and 
      after the onset of skin rash (skin rash-related viremia) in nine cases in group 
      A. Meanwhile, no skin rash-related viremia was observed in group B. Of the four 
      recipients with positive detection of HHV-6 genome in their skin tissue (group 
      A), two had HHV-6 viremia at the same time. The association between the timing of 
      HHV-6 infection and the onset of skin rash was analyzed statistically. HHV-6 
      viremia (skin rash-related viremia) was found in nine of 15 (60%) cases in group 
      A, compared with none of 10 (0%) cases in group B. This difference was 
      statistically significant (P = 0.008). Moreover, HHV-6 infection (skin 
      rash-related viremia and/or positive detection of HHV-6 DNA in skin tissue) was 
      demonstrated in 11 of 15 (73.3%) cases in group A, compared with none of 10 (0%) 
      cases in group B (P = 0.001). Thus, this study suggests that HHV-6 may be 
      involved in the development of skin rash in the first month after allogeneic BMT.
FAU - Yoshikawa, T
AU  - Yoshikawa T
AD  - Laboratory of Virology, Research Institute for Disease Mechanism and Control, 
      Nagoya University School of Medicine, Nagoya, Japan.
FAU - Ihira, M
AU  - Ihira M
FAU - Ohashi, M
AU  - Ohashi M
FAU - Suga, S
AU  - Suga S
FAU - Asano, Y
AU  - Asano Y
FAU - Miyazaki, H
AU  - Miyazaki H
FAU - Hirano, M
AU  - Hirano M
FAU - Suzuki, K
AU  - Suzuki K
FAU - Matsunaga, K
AU  - Matsunaga K
FAU - Horibe, K
AU  - Horibe K
FAU - Kojima, S
AU  - Kojima S
FAU - Kudo, K
AU  - Kudo K
FAU - Kato, K
AU  - Kato K
FAU - Matsuyama, T
AU  - Matsuyama T
FAU - Nishiyama, Y
AU  - Nishiyama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Child
MH  - Child, Preschool
MH  - DNA, Viral/blood
MH  - Exanthema/etiology/*virology
MH  - Female
MH  - Herpesviridae Infections/complications/*pathology
MH  - Herpesvirus 6, Human/*growth & development
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Time Factors
MH  - Transplantation, Homologous/adverse effects
MH  - Virus Activation
EDAT- 2001/08/11 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/11 10:00
PHST- 2001/01/03 00:00 [received]
PHST- 2001/04/04 00:00 [accepted]
PHST- 2001/08/11 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/11 10:00 [entrez]
AID - 10.1038/sj.bmt.1703099 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2001 Jul;28(1):77-81. doi: 10.1038/sj.bmt.1703099.