PMID- 11500009
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20200423
IS  - 1050-0545 (Print)
IS  - 1050-0545 (Linking)
VI  - 12
IP  - 7
DP  - 2001 Jul-Aug
TI  - Possible neuronal refractory or recovery artifacts associated with recording the 
      mismatch negativity response.
PG  - 348-56
AB  - The mismatch negativity (MMN) is an event-related potential that involves a 
      negative voltage shift of baseline electroencephalographic (EEG) activity in the 
      approximate latency window of the N1 and P2 cortical potentials in response to 
      new or novel sounds. The MMN is present at birth and has been hypothesized to 
      serve as an automatic preconscious detector of changes in the auditory 
      environment. Research paradigms used to extract the MMN response from EEG 
      activity have a potential problem related to neuronal refractoriness or recovery. 
      Both N1 and P2 are known to increase in amplitude with longer interstimulus 
      intervals (ISIs). The MMN extraction procedures involve mathematical subtraction 
      of waveforms elicited by standard sounds (with short ISIs) from those recorded to 
      rare deviant sounds (with longer ISIs). Any ISI-dependent amplitude changes in N1 
      and/or P2 could therefore alter the morphology of the resulting difference wave 
      and lead to misinterpretation of the nature of the underlying MMN generators. We 
      tested 12 young females and found that the MMN can be influenced by ISI-dependent 
      refractory effects that may modify the waveform morphology. This has important 
      clinical implications since the MMN is being investigated as an assessment tool.
FAU - Walker, L J
AU  - Walker LJ
AD  - Department of Communication Sciences, East Carolina University, Greenville, North 
      Carolina 27858, USA.
FAU - Carpenter, M
AU  - Carpenter M
FAU - Downs, C R
AU  - Downs CR
FAU - Cranford, J L
AU  - Cranford JL
FAU - Stuart, A
AU  - Stuart A
FAU - Pravica, D
AU  - Pravica D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Audiol
JT  - Journal of the American Academy of Audiology
JID - 9114646
SB  - IM
MH  - Adult
MH  - *Artifacts
MH  - Audiometry, Pure-Tone
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/physiology
MH  - Female
MH  - Hearing/*physiology
MH  - Humans
MH  - Male
MH  - Neurons/*physiology
EDAT- 2001/08/14 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/14 10:00
PHST- 2001/08/14 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/14 10:00 [entrez]
PST - ppublish
SO  - J Am Acad Audiol. 2001 Jul-Aug;12(7):348-56.