PMID- 11503910
OWN - NLM
STAT- MEDLINE
DCOM- 20020205
LR  - 20190605
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 63
IP  - 7
DP  - 2001 Jul
TI  - Activation of GABA(A) receptors in the accessory olfactory bulb does not prevent 
      the formation of an olfactory memory in mice.
PG  - 807-9
AB  - When female mice are mated, they form a memory to the pheromonal signal of their 
      male partner. The neural mechanisms underlying this memory involve changes at the 
      reciprocal dendrodendritic synapses between glutamatergic mitral cells and 
      gamma-aminobutyric acid (GABA)-ergic granule cells in the accessory olfactory 
      bulb (AOB). Blockade of GABA(A) receptors in the AOB leads to the formation of an 
      olfactory memory. In an attempt to disrupt memory formation at mating, we used 
      local infusions of the GABA(A) receptor agonist muscimol into the AOB during the 
      critical period for memory formation. Muscimol across a wide range of doses 
      (1-1000 pmol) did not prevent memory formation. The resistance of this memory to 
      GABA(A) receptor activation may reflect the complexity of synaptic microcircuits 
      in the AOB.
FAU - Otsuka, T
AU  - Otsuka T
AD  - Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima 
      University, Japan.
FAU - Hashida, M
AU  - Hashida M
FAU - Oka, T
AU  - Oka T
FAU - Kaba, H
AU  - Kaba H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (GABA Agonists)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Sex Attractants)
RN  - 2763-96-4 (Muscimol)
SB  - IM
MH  - Animals
MH  - Female
MH  - GABA Agonists/pharmacology
MH  - Male
MH  - Memory/drug effects/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred CBA
MH  - Muscimol/pharmacology
MH  - Olfactory Bulb/drug effects/*physiology
MH  - Pregnancy
MH  - Receptors, GABA-A/drug effects/*physiology
MH  - Sex Attractants/physiology
EDAT- 2001/08/16 10:00
MHDA- 2002/02/06 10:01
CRDT- 2001/08/16 10:00
PHST- 2001/08/16 10:00 [pubmed]
PHST- 2002/02/06 10:01 [medline]
PHST- 2001/08/16 10:00 [entrez]
AID - 10.1292/jvms.63.807 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2001 Jul;63(7):807-9. doi: 10.1292/jvms.63.807.