PMID- 11506401
OWN - NLM
STAT- MEDLINE
DCOM- 20011220
LR  - 20220331
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 50
IP  - 2
DP  - 2001 Aug
TI  - Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission 
      in human epileptic dentate gyrus.
PG  - 188-94
AB  - Brain-derived neurotrophic factor (BDNF) has trophic effects and modulates 
      synaptic transmission in the hippocampal formation in animal studies. It is also 
      upregulated in acute and chronic epilepsy models and in human temporal lobe 
      epilepsy. This study was undertaken to examine the effects of BDNF on fast 
      synaptic transmission in the human epileptic dentate gyrus. Hippocampal specimens 
      were acquired from patients with temporal lobe epilepsy during surgical removal 
      of the anterior temporal lobe intended to treat the epileptic condition. 
      Whole-cell patch-clamp recordings were obtained from dentate granule cells in 
      transverse hippocampal slices in vitro. Application of BDNF increased the 
      amplitude and frequency of spontaneous excitatory postsynaptic currents and 
      increased the amplitude of evoked excitatory postsynaptic currents. BDNF had no 
      effect on spontaneous inhibitory postsynaptic currents but produced a decrease in 
      amplitude of evoked inhibitory postsynaptic currents. BDNF's effects were 
      abolished by coapplication of the tyrosine kinase inhibitor K252a. Therefore, 
      BDNF enhances fast excitatory transmission in the epileptic human dentate gyrus 
      and may play an important role in epileptogenesis in temporal lobe epilepsy. This 
      raises the possibility of designing therapies for this disorder that may be both 
      anticonvulsant and antiepileptogenic.
FAU - Zhu, W J
AU  - Zhu WJ
AD  - Department of Neurological Surgery and Evelyn F. and William L. McKnight Brain 
      Institute, University of Florida, Gainesville 32610-0265, USA.
FAU - Roper, S N
AU  - Roper SN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Dentate Gyrus/*pathology/*physiopathology
MH  - Epilepsy/*pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Synaptic Transmission/*drug effects/physiology
MH  - Time Factors
EDAT- 2001/08/17 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/17 10:00
PHST- 2001/08/17 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/17 10:00 [entrez]
AID - 10.1002/ana.1074 [doi]
PST - ppublish
SO  - Ann Neurol. 2001 Aug;50(2):188-94. doi: 10.1002/ana.1074.