PMID- 11506471
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20190915
IS  - 0903-4641 (Print)
IS  - 0903-4641 (Linking)
VI  - 109
IP  - 6
DP  - 2001 Jun
TI  - Human herpesvirus 6 in the pathogenesis of multiple sclerosis.
PG  - 401-11
AB  - Multiple sclerosis (MS) is one of the most common disabling neurological diseases 
      affecting young adults. It is a chronic disease characterised by inflammation and 
      demyelination. The aetiology of MS is still unknown, but involvement of viruses 
      has been suspected for many years. Recently much interest has focused on human 
      herpesvirus 6 (HHV-6), since the virus has been detected in MS plaques in the 
      brain and patients with MS have been shown to have an aberrant immune response to 
      HHV-6. Results from different studies are, however, conflicting and in the light 
      of the long list of previous claims to have found the viral aetiology of MS it is 
      necessary to interpret the HHV-6 findings with great caution. Possible mechanisms 
      for virally induced demyelination and autoimmunity are discussed in this review, 
      and the evidence for and against a role for HHV-6 in MS is summarised.
FAU - Enbom, M
AU  - Enbom M
AD  - Department of Virology, Swedish Institute for Infectious Disease Control, Solna. 
      malin_enbom@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (Antigens, CD)
RN  - 0 (CD46 protein, human)
RN  - 0 (Membrane Cofactor Protein)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Antigens, CD/metabolism
MH  - Epidemiologic Factors
MH  - Herpesviridae/pathogenicity
MH  - Herpesviridae Infections/complications
MH  - Herpesvirus 6, Human/immunology/isolation & purification/*pathogenicity
MH  - Humans
MH  - Measles virus/pathogenicity
MH  - Membrane Cofactor Protein
MH  - Membrane Glycoproteins/metabolism
MH  - Multiple Sclerosis/epidemiology/*etiology/immunology/virology
MH  - Receptors, Virus/metabolism
MH  - Retroviridae/pathogenicity
RF  - 109
EDAT- 2001/08/17 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/08/17 10:00
PHST- 2001/08/17 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/08/17 10:00 [entrez]
AID - 10.1034/j.1600-0463.2001.090601.x [doi]
PST - ppublish
SO  - APMIS. 2001 Jun;109(6):401-11. doi: 10.1034/j.1600-0463.2001.090601.x.