PMID- 11508661
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20220318
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 46
IP  - 8
DP  - 2001 Aug
TI  - Brain-derived neurotrophic factor (BDNF) is upregulated and associated with pain 
      in chronic pancreatitis.
PG  - 1633-9
AB  - Our purpose was to investigate brain-derived neurotrophic factor (BDNF) in 
      chronic pancreatitis (CP) in comparison with the normal pancreas and to evaluate 
      its association with pain. By immunohistochemistry, in the normal pancreas BDNF 
      immunoreactivity was moderately present in the cytoplasm of most ductal cells and 
      weakly present in most acinar cells, islet cells, nerve fibers (including 
      perineurium), and ganglia cells. In contrast, in CP intense immunostaining of 
      BDNF was present in most cells of ductular complexes and in the perineurium of 
      enlarged nerves. Moderate immunostaining of BDNF was found in degenerating acinar 
      cells and islet cells. In addition, moderate immunoreactivity of BDNF was also 
      detected in most enlarged nerve fibers and intrinsic pancreatic ganglia cells in 
      CP samples. Western blot analysis also revealed 5.6-fold higher BDNF levels in CP 
      samples (P < 0.01) compared with normal pancreas samples. The expression level of 
      BDNF was positively correlated with pain intensity (P < 0.01) and pain frequency 
      (P < 0.01) of CP patients. Furthermore, there was a significant relationship (r = 
      0.68, P < 0.01) between the BDNF immunostaining and the global pain scores. BDNF 
      is increased in CP. Its association with pain suggests that it functions as a 
      peripheral and central pain modulator, as reported previously in other 
      inflammatory disorders.
FAU - Zhu, Z W
AU  - Zhu ZW
AD  - Department of Visceral and Transplantation Surgery, University of Bern, 
      Inselspital, Switzerland.
FAU - Friess, H
AU  - Friess H
FAU - Wang, L
AU  - Wang L
FAU - Zimmermann, A
AU  - Zimmermann A
FAU - Buchler, M W
AU  - Buchler MW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Islets of Langerhans/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pain/etiology/*metabolism
MH  - Pancreas/*metabolism
MH  - Pancreatitis/complications/*metabolism
MH  - Up-Regulation
EDAT- 2001/08/18 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/08/18 10:00
PHST- 2001/08/18 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/08/18 10:00 [entrez]
AID - 10.1023/a:1010684916863 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2001 Aug;46(8):1633-9. doi: 10.1023/a:1010684916863.