PMID- 11509689
OWN - NLM
STAT- MEDLINE
DCOM- 20011018
LR  - 20190513
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 16 Suppl 5
DP  - 2001
TI  - Leptospirosis renal disease.
PG  - 73-7
AB  - Leptospirosis is a re-emerging infectious disease, affecting both animals and 
      humans worldwide. Multiple organ involvement may be encountered in leptospirosis, 
      and early renal involvement is very common, characterized by tubulo-interstitial 
      nephritis and tubular dysfunction. All 12 patients diagnosed in Chang Gung 
      Memorial Hospital (Taiwan) between 1997 and 1999 had acute renal failure, with 
      five patients requiring dialysis. Leptospira shermani is the main serovar 
      encountered in Taiwan, and penicillin may dramatically rescue patients from 
      multiple organ failure provided it is given early. To understand the mechanism 
      behind tubular injuries by leptospira infection, outer membrane proteins (OMPs) 
      extracted from pathogenic leptospira were given to tubular cells in culture. Our 
      in vitro experiment showed that OMPs of pathogenic leptospira activate nuclear 
      NFkappaB binding and stimulate downstream inducible nitric oxide (iNOS), monocyte 
      chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) 
      expression. These results indicate that leptospiral infection may induce 
      tubulo-interstitial nephritis through a toxic component in the outer membrane 
      followed by expression of inflammatory genes.
FAU - Yang, C W
AU  - Yang CW
AD  - Department of Nephrology, Chang Gung Memorial Hospital and Graduate Institute of 
      Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Wu, M S
AU  - Wu MS
FAU - Pan, M J
AU  - Pan MJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Endotoxins)
RN  - 0 (NF-kappa B)
RN  - 0 (Penicillins)
SB  - IM
MH  - Acute Kidney Injury/etiology
MH  - Animals
MH  - Endotoxins/physiology
MH  - Humans
MH  - Kidney Diseases/complications/*microbiology/*therapy
MH  - Kidney Tubules/metabolism
MH  - Leptospirosis/complications/*etiology/*therapy
MH  - NF-kappa B/physiology
MH  - Nephritis, Interstitial/microbiology/physiopathology
MH  - Penicillins/therapeutic use
MH  - Thrombocytopenia/microbiology
RF  - 27
EDAT- 2001/08/18 10:00
MHDA- 2001/10/19 10:01
CRDT- 2001/08/18 10:00
PHST- 2001/08/18 10:00 [pubmed]
PHST- 2001/10/19 10:01 [medline]
PHST- 2001/08/18 10:00 [entrez]
AID - 10.1093/ndt/16.suppl_5.73 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2001;16 Suppl 5:73-7. doi: 10.1093/ndt/16.suppl_5.73.