PMID- 11509978
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20131121
IS  - 0032-0943 (Print)
IS  - 0032-0943 (Linking)
VI  - 67
IP  - 6
DP  - 2001 Aug
TI  - A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-alpha release 
      from Curcuma zedoaria.
PG  - 550-2
AB  - Tumor necrosis factor-alpha (TNF-alpha) is one of the major mediators produced in 
      activated macrophages which contribute to the circulatory failure associated with 
      septic shock. In the course of screening marketed oriental anti-inflammatory 
      herbal drugs for TNF-alpha antagonistic activity, a crude methanolic extract of 
      the rhizomes of Curcuma zedoaria exhibited significant activity. The 
      activity-guided fractionation and repetitive chromatographic procedures with the 
      EtOAc-soluble fraction resulted in the isolation of three active compounds. They 
      were identified as 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (1), 
      procurcumenol (2) and epiprocurcumenol (3) by spectral data analysis. They 
      inhibited the production of TNF-alpha by lipopolysaccharide (LPS)-activated 
      macrophages from the results of bioassay (IC(50) values of 1 and 2 are 12.3 and 
      310.5 microM, respectively) and Western blot assay. These results imply that the 
      traditional use of C. zedoaria rhizome as anti-inflammatory drug may be explained 
      at least in part, by the inhibition of TNF-alpha production.
FAU - Jang, M K
AU  - Jang MK
FAU - Sohn, D H
AU  - Sohn DH
FAU - Ryu, J H
AU  - Ryu JH
LA  - eng
PT  - Letter
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Sesquiterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 21698-40-8 (procurcumenol)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/isolation & purification/*pharmacology
MH  - Biological Assay
MH  - Blotting, Western
MH  - Cell Line
MH  - Cell Survival
MH  - Curcumin/analogs & derivatives/*pharmacology
MH  - Inhibitory Concentration 50
MH  - Macrophages/*drug effects
MH  - Magnetic Resonance Spectroscopy
MH  - Phenols/chemistry/isolation & purification/*pharmacology
MH  - Plant Extracts/pharmacology
MH  - Plant Structures/chemistry
MH  - Plants, Medicinal/chemistry
MH  - Sesquiterpenes/chemistry/isolation & purification/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Zingiberaceae/*chemistry
EDAT- 2001/08/18 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/18 10:00
PHST- 2001/08/18 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/18 10:00 [entrez]
AID - 10.1055/s-2001-16482 [doi]
PST - ppublish
SO  - Planta Med. 2001 Aug;67(6):550-2. doi: 10.1055/s-2001-16482.