PMID- 11510296
OWN - NLM
STAT- MEDLINE
DCOM- 20020123
LR  - 20041117
IS  - 1197-8554 (Print)
IS  - 1197-8554 (Linking)
VI  - 17
DP  - 2001
TI  - Parathyroid hormone contributes to variations in blood morphology in diabetic and 
      non diabetic patients treated with continuous ambulatory peritoneal dialysis.
PG  - 5-9
AB  - The present study looked for variations in blood morphology between diabetic 
      patients (group I, n = 7) and non diabetic patients (group II, n = 16) treated 
      with continuous ambulatory peritoneal dialysis (CAPD). A subsequent trial sought 
      to find a reason for discrepancies in the results between the two groups. The 
      patients in both groups and similar ages, CAPD durations, and erythropoietin 
      dosages. Nutrition, CAPD adequacy, serum iron and ferritin levels, total iron 
      binding capacity (TIBC), transferrin saturation (TSAT), red blood cells (RBCs), 
      mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), mean 
      corpuscular hemoglobin concentration (MCHC), hemoglobin (Hb), hematocrit (Hct), 
      white blood cells (WBCs), total lymphocyte count (TLC), platelets (PLTs), and 
      serum intact parathyroid hormone (PTH) were evaluated every three months. The 
      mean result of each parameter was obtained in every patient as representative for 
      the entire CAPD course. Means and standard deviations for all respective 
      parameters were then calculated for the two groups and compared. In patients with 
      diabetes as compared with patients without diabetes, significantly higher numbers 
      of RBCs, WBCs, and PLTs were seen, as were higher values for Hb and Hct and a 
      lower serum PTH concentration. Values for WBCs, PLTs, and MCH obtained in all 
      patients (n = 23) were correlated with serum intact PTH (r = -0.520, p = 0.011; r 
      = -0.422, p = 0.045; and r = -0.436, p = 0.037 respectively). When data obtained 
      in the patients receiving erythropoietin were excluded and the correlation 
      analysis was repeated for the 10 remaining patients, a correlation between serum 
      PTH and RBCs was found (r = -0.685, p = 0.029). With comparable age, renal 
      function, nutrition, erythropoietin dosage, iron indices, and CAPD adequacy, 
      duration, and outcome, higher parameters of blood morphology in diabetic patients 
      may be related to lower levels of serum intact PTH, indicating no or only mild 
      secondary hyperparathyroidism. Patients with diabetes usually show smaller 
      disturbances in PTH level than do non diabetic uremic patients on CAPD. Better 
      peripheral morphology indices in the group with diabetes can be expected when 
      other factors affecting hematologic status are similar.
FAU - Grzegorzewska, A E
AU  - Grzegorzewska AE
AD  - Department of Nephrology, Karol Marcinkowski University of Medical Sciences, 
      Poznan, Poland.
FAU - Mariak, I
AU  - Mariak I
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Adv Perit Dial
JT  - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis
JID - 9104803
RN  - 0 (Hemoglobins)
RN  - 0 (Parathyroid Hormone)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Adult
MH  - *Blood Cell Count
MH  - Diabetes Mellitus/*blood
MH  - Diabetic Nephropathies/*therapy
MH  - Erythropoietin/therapeutic use
MH  - Female
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/blood/*physiology
MH  - *Peritoneal Dialysis, Continuous Ambulatory
MH  - Retrospective Studies
EDAT- 2001/08/21 10:00
MHDA- 2002/01/24 10:01
CRDT- 2001/08/21 10:00
PHST- 2001/08/21 10:00 [pubmed]
PHST- 2002/01/24 10:01 [medline]
PHST- 2001/08/21 10:00 [entrez]
PST - ppublish
SO  - Adv Perit Dial. 2001;17:5-9.