PMID- 11511199
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20190814
IS  - 0020-1669 (Print)
IS  - 0020-1669 (Linking)
VI  - 40
IP  - 18
DP  - 2001 Aug 27
TI  - Zn(II), Ni(II), Cu(II), and Fe(III) complexes of potentially bimetalating 
      tris(pyridine- and imidazole-appended) picket-fence naphthylporphyrins with 
      benzyl ether spacers: implications for cytochrome c oxidase active-site modeling.
PG  - 4556-62
AB  - Two new unsymmetrical picket-fence naphthylporphyrin ligands, 1 and 2, and 
      several of their metalated porphyrinato complexes have been synthesized as 
      precursor model compounds for the binuclear (Fe/Cu) cytochrome c oxidase (CcO) 
      active site. 1 and 2 have a naphthylporphyrin superstructure that has been 
      specifically incorporated to confer long-term configurational stability to the 
      atropisomeric products. The two picket-fence porphyrin ligands also bear 
      covalently linked, axially offset tris(heterocycle) coordination sites for a 
      copper ion, much like that found in the native enzyme. Monometallic porphyrin 
      complexes [M = Zn(II), Ni(II), Cu(II), and Fe(III)] of the pyridine-appended 
      ligand 1 have been prepared and spectroscopically and magnetically characterized. 
      An unusual monomeric iron(III) hydroxo porphyrin complex was isolated upon workup 
      of the compound formed under ferrous sulfate/acetic acid reflux conditions. There 
      is general difficulty in forming binuclear complexes of 1, which is attributed to 
      the conformational flexibility of the benzyl ether type picket spacers. The 
      potential of ligands such as 1 and 2 for future CcO active-site modeling studies 
      is considered.
FAU - Thrash, T P
AU  - Thrash TP
AD  - Department of Chemistry and the Center for Nanoscale Science and Technology, M.S. 
      60, Rice University, P.O. Box 1892, Houston, Texas 77251-1892, USA.
FAU - Wilson, L J
AU  - Wilson LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inorg Chem
JT  - Inorganic chemistry
JID - 0366543
RN  - 0 (Metalloporphyrins)
RN  - 789U1901C5 (Copper)
RN  - 7OV03QG267 (Nickel)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Binding Sites
MH  - *Copper
MH  - Electron Transport Complex IV/*chemistry
MH  - *Iron
MH  - Magnetic Resonance Spectroscopy
MH  - Metalloporphyrins/*chemistry
MH  - Models, Molecular
MH  - *Nickel
MH  - Spectrometry, Mass, Fast Atom Bombardment
MH  - Spectrophotometry, Infrared
MH  - Spectrophotometry, Ultraviolet
MH  - *Zinc
EDAT- 2001/08/21 10:00
MHDA- 2001/10/12 10:01
CRDT- 2001/08/21 10:00
PHST- 2001/08/21 10:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/08/21 10:00 [entrez]
AID - ic001274q [pii]
AID - 10.1021/ic001274q [doi]
PST - ppublish
SO  - Inorg Chem. 2001 Aug 27;40(18):4556-62. doi: 10.1021/ic001274q.