PMID- 11512080
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20171116
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 33
IP  - 6
DP  - 2001 Sep 15
TI  - Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow 
      transplant recipients.
PG  - 763-71
AB  - To determine whether receipt of an investigational anti-CD3 monoclonal antibody 
      (BC3) increased the risk of human herpesvirus 6 (HHV-6) reactivation and 
      development of encephalitis in bone marrow transplant (BMT) recipients, persons 
      who had and had not received BC3 were compared. Odds of HHV-6 reactivation were 
      higher among BC3 recipients than among control patients (odds ratio, 2.5; 95% 
      confidence interval [CI], 1.3-4.7). In addition, BC3 recipients were more likely 
      than control patients to develop encephalitis (risk ratio [RR], 3.5; 95% CI, 
      1.3-9.5), and this association followed a BC3 dose-dependent relationship (P=.03, 
      by Mantel-Haenszel chi(2) test). In a multivariable model, HHV-6 reactivation and 
      receipt of BC3 were associated with increased risk of encephalitis (RR, 5.4; 95% 
      CI, 1.9-15.3, and RR, 3.3; 95% CI, 1.2-9.1, respectively). In conclusion, both 
      HHV-6 reactivation and receipt of BC3 for prophylaxis of acute graft-versus-host 
      disease independently increased the risk of encephalitis in allogeneic BMT 
      recipients. Prospective studies to better define the relationship between HHV-6 
      reactivation and encephalitis in allogeneic BMT recipients are warranted.
FAU - Zerr, D M
AU  - Zerr DM
AD  - Department of Pediatrics, University of Washington, Seattle, WA, USA. 
      zerr@u.washington.edu
FAU - Gooley, T A
AU  - Gooley TA
FAU - Yeung, L
AU  - Yeung L
FAU - Huang, M L
AU  - Huang ML
FAU - Carpenter, P
AU  - Carpenter P
FAU - Wade, J C
AU  - Wade JC
FAU - Corey, L
AU  - Corey L
FAU - Anasetti, C
AU  - Anasetti C
LA  - eng
GR  - AI-01679/AI/NIAID NIH HHS/United States
GR  - AI-30731/AI/NIAID NIH HHS/United States
GR  - CA-18029/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Clinical Trial
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20010813
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD3 Complex)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal/administration & dosage/*adverse effects
MH  - Bone Marrow Transplantation/*adverse effects/immunology
MH  - CD3 Complex
MH  - Encephalitis, Viral/*etiology
MH  - Female
MH  - Graft vs Host Disease/prevention & control
MH  - Herpesviridae Infections/*etiology
MH  - Herpesvirus 6, Human/genetics/isolation & purification/*pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Risk Factors
EDAT- 2001/08/21 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/21 10:00
PHST- 2000/11/13 00:00 [received]
PHST- 2001/01/25 00:00 [revised]
PHST- 2001/08/21 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/21 10:00 [entrez]
AID - CID001544 [pii]
AID - 10.1086/322642 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2001 Sep 15;33(6):763-71. doi: 10.1086/322642. Epub 2001 Aug 13.