PMID- 11513549
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20071114
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 100
IP  - 3
DP  - 2001 Sep
TI  - Infection of human B lymphocytes with MMR vaccine induces IgE class switching.
PG  - 355-61
AB  - Circulating immunoglobulin E (IgE) is one of the characteristics of human 
      allergic diseases including allergic asthma. We recently showed that infection of 
      human B cells with rhinovirus or measles virus could lead to the initial steps of 
      IgE class switching. Since many viral vaccines are live viruses, we speculated 
      that live virus vaccines may also induce IgE class switching in human B cells. To 
      examine this possibility, we selected the commonly used live attenuated measles 
      mumps rubella (MMR) vaccine. Here, we show that infection of a human IgM(+) B 
      cell line with MMR resulted in the expression of germline epsilon transcript. In 
      addition, infection of freshly prepared human PBLs with this vaccine resulted in 
      the expression of mature IgE mRNA transcript. Our data suggest that a potential 
      side effect of vaccination with live attenuated viruses may be an increase in the 
      expression of IgE.
CI  - Copyright 2001 Academic Press.
FAU - Imani, F
AU  - Imani F
AD  - Division of Clinical Immunology, Department of Medicine, The Johns Hopkins 
      University School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview 
      Circle, Baltimore, Maryland 21224, USA. fimani@mail.jhmi.edu
FAU - Kehoe, K E
AU  - Kehoe KE
LA  - eng
GR  - AI44696/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Measles-Mumps-Rubella Vaccine)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - B-Lymphocytes/*metabolism/virology
MH  - Humans
MH  - *Immunoglobulin Class Switching
MH  - Immunoglobulin E/*biosynthesis/genetics
MH  - Measles-Mumps-Rubella Vaccine/*adverse effects
MH  - RNA, Messenger/analysis
MH  - Tumor Cells, Cultured
EDAT- 2001/08/22 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/08/22 10:00
PHST- 2001/08/22 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/08/22 10:00 [entrez]
AID - S1521-6616(01)95073-9 [pii]
AID - 10.1006/clim.2001.5073 [doi]
PST - ppublish
SO  - Clin Immunol. 2001 Sep;100(3):355-61. doi: 10.1006/clim.2001.5073.