PMID- 11513842
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 425
IP  - 3
DP  - 2001 Aug 17
TI  - Role of nitric oxide in histamine release from human basophils and rat peritoneal 
      mast cells.
PG  - 229-38
AB  - The effects of a range of nitric oxide (NO)-related compounds on histamine 
      release from human basophils and rat peritoneal mast cells were studied. Basal 
      and immunologic histamine releases from human basophils were not affected by 
      N(omega)-nitro-L-arginine, N(omega)-nitro-L-arginine methyl ester, aminoguanidine 
      or methylene blue (all inhibitors of NO production), sodium nitroprusside (an NO 
      donor), L-arginine (a substrate for NO synthase) or D-arginine (the inactive 
      enantiomer of L-arginine). In rat peritoneal mast cells, NO donors such as sodium 
      nitroprusside, sodium nitrite and sodium nitrate, and lipopolysaccharide (an 
      inducer of NO synthase) had little effect on basal histamine release, while 
      3-morpholino-sydnonimine (SIN-1, an NO donor), L-arginine and D-arginine 
      increased this release by up to threefold. None of the inhibitors of NO 
      production had any striking effect on histamine release induced by anti-rat 
      immunoglobulin E (IgE), compound 48/80, sodium fluoride, phospholipase C, 
      1,2-dioctanoyl-sn-glycerol or ionophore A23187. However, haemoglobin was found to 
      inhibit histamine release by anti-rat IgE or A23187 by ca. 40%. Alone of the NO 
      donors, low concentrations of L-arginine produced a mild inhibition of histamine 
      release induced by anti-IgE, compound 48/80 and A23187, but not other ligands, 
      while sodium nitroprusside dose-dependently inhibited (by a maximum of ca. 30%) 
      histamine release by anti-rat IgE, sodium fluoride or A23187. Stimulation with a 
      variety of secretagogues or treatment with L-arginine, D-arginine, 
      lipopolysaccharide, SIN-1 or sodium nitroprusside had no effect on NO production. 
      Similarly, L-arginine, D-arginine or sodium nitroprusside did not change 
      intracellular cGMP levels. On the basis of these results, it is suggested that NO 
      does not play a significant role in the modulation of histamine release from 
      human basophils or rat peritoneal mast cells. The effects of L-arginine, 
      D-arginine and sodium nitroprusside may involve mechanisms unrelated to NO.
FAU - Peh, K H
AU  - Peh KH
AD  - Department of Pharmacology, University College London, Gower Street, WC1E 6BT, 
      London, UK.
FAU - Moulson, A
AU  - Moulson A
FAU - Wan, B Y
AU  - Wan BY
FAU - Assem, E K
AU  - Assem EK
FAU - Pearce, F L
AU  - Pearce FL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antibodies)
RN  - 0 (Guanidines)
RN  - 0 (Hemoglobins)
RN  - 0 (Nitrates)
RN  - 0 (Nitric Oxide Donors)
RN  - 169D1260KM (Nitroprusside)
RN  - 2149-70-4 (Nitroarginine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 5O5U71P6VQ (linsidomine)
RN  - 820484N8I3 (Histamine)
RN  - 8M4L3H2ZVZ (sodium nitrate)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - 94ZLA3W45F (Arginine)
RN  - D46583G77X (Molsidomine)
RN  - M0KG633D4F (Sodium Nitrite)
RN  - SCQ4EZQ113 (pimagedine)
RN  - T42P99266K (Methylene Blue)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Arginine/pharmacology
MH  - Basophils/cytology/drug effects/*metabolism
MH  - Calcimycin/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Guanidines/pharmacology
MH  - Hemoglobins/pharmacology
MH  - Histamine/*metabolism
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mast Cells/cytology/drug effects/*metabolism
MH  - Methylene Blue/pharmacology
MH  - Molsidomine/analogs & derivatives/pharmacology
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitrates/pharmacology
MH  - Nitric Oxide/biosynthesis/*physiology
MH  - Nitric Oxide Donors/pharmacology
MH  - Nitroarginine/pharmacology
MH  - Nitroprusside/pharmacology
MH  - Peritoneal Cavity/cytology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Fluoride/pharmacology
MH  - Sodium Nitrite/pharmacology
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2001/08/22 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/08/22 10:00
PHST- 2001/08/22 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/08/22 10:00 [entrez]
AID - S0014299901012055 [pii]
AID - 10.1016/s0014-2999(01)01205-5 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2001 Aug 17;425(3):229-38. doi: 10.1016/s0014-2999(01)01205-5.