PMID- 11516089
OWN - NLM
STAT- MEDLINE
DCOM- 20020219
LR  - 20190815
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 22
IP  - 18
DP  - 2001 Sep
TI  - Preparation of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams by 
      use of ice microparticulates.
PG  - 2563-7
AB  - Biodegradable foams of poly(L-lactic acid) (PLLA) and poly(DL-lactic-co-glycolic 
      acid) (PLGA) for tissue engineering were fabricated by a porogen-leaching 
      technique using ice microparticulates as the porogen material. PLLA or PLGA 
      solution in chloroform was mixed with ice microparticulates. The mixtures were 
      frozen by being placed in molds in liquid nitrogen and freeze-dried to form the 
      foams. Scanning electron microscopic observation of the PLLA and PLGA foams 
      showed that evenly distributed and interconnected pore structures were formed in 
      these foams. The porosity and surface area of the foams increased with an 
      increase in the weight fraction of the ice microparticulates, while the median 
      pore size remained unchanged. The pore structures of the foams could be 
      manipulated by controlling processing variables such as the size and weight 
      fraction of the ice microparticulates and polymer concentration.
FAU - Chen, G
AU  - Chen G
AD  - 3D Tissue Engineering Group, National Institute for Advanced Interdisciplinary 
      Research, Tsukuba, Ibaraki, Japan. chen@nair.go.jp
FAU - Ushida, T
AU  - Ushida T
FAU - Tateishi, T
AU  - Tateishi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Ice)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Biocompatible Materials/*isolation & purification
MH  - Biodegradation, Environmental
MH  - Freeze Drying
MH  - Ice
MH  - Lactic Acid/*isolation & purification
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Particle Size
MH  - Polyesters
MH  - Polyglycolic Acid/*isolation & purification
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*isolation & purification
EDAT- 2001/08/23 10:00
MHDA- 2002/02/20 10:01
CRDT- 2001/08/23 10:00
PHST- 2001/08/23 10:00 [pubmed]
PHST- 2002/02/20 10:01 [medline]
PHST- 2001/08/23 10:00 [entrez]
AID - S0142961200004476 [pii]
AID - 10.1016/s0142-9612(00)00447-6 [doi]
PST - ppublish
SO  - Biomaterials. 2001 Sep;22(18):2563-7. doi: 10.1016/s0142-9612(00)00447-6.