PMID- 11516565
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 307
IP  - 1
DP  - 2001 Jul 6
TI  - Pre- and postnatal expression of brain-derived neurotrophic factor mRNA/protein 
      and tyrosine protein kinase receptor B mRNA in the mouse hippocampus.
PG  - 21-4
AB  - Brain-derived neurotrophic factor (BDNF) is implicated in the control of 
      hippocampal development. In this study, we have analyzed the developmental 
      expression of BDNF mRNA/protein and its receptor tyrosine protein kinase receptor 
      (trk) B mRNA in the mouse hippocampus by competitive reverse 
      transcription/polymerase chain reaction and enzyme-linked immunoassay. Cell-type 
      specificity of BDNF/trkB expression was studied in primary hippocampal cultures. 
      BDNF levels increased stepwise from embryonic day 15 until the second postnatal 
      week, whereas trkB expression was stable throughout development. Neurons and 
      astrocytes expressed both BDNF and trkB. Our data suggest that developmental BDNF 
      action mainly occurs postnatally and indicates that hippocampal neurons and 
      astroglia not only produce BDNF but also appear to be targets for BDNF.
FAU - Ivanova, T
AU  - Ivanova T
AD  - Abteilung Anatomie und Zellbiologie, Universitat Ulm, D-89069 Ulm, Germany.
FAU - Beyer, C
AU  - Beyer C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cells, Cultured
MH  - Female
MH  - Hippocampus/growth & development/*metabolism/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Receptor, trkB/*genetics
MH  - Sex Factors
EDAT- 2001/08/23 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/08/23 10:00
PHST- 2001/08/23 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/08/23 10:00 [entrez]
AID - S0304-3940(01)01905-X [pii]
AID - 10.1016/s0304-3940(01)01905-x [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Jul 6;307(1):21-4. doi: 10.1016/s0304-3940(01)01905-x.