PMID- 11524143
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 310
IP  - 1
DP  - 2001 Sep 7
TI  - Gene expression profiling of the tau mutant (P301L) transgenic mouse brain.
PG  - 1-4
AB  - To provide a global analysis of the influence of Tau neuropathology at molecular 
      level, we used cDNA arrays representing 8832 genes to determine the mRNA 
      expression profile in transgenic mice expressing the most common frontotemporal 
      dementia and parkinsonism linked to chromosome 17 (FTDP-17) Tau mutation (P301L) 
      (Nat. Genet. (2000) 402). Genes whose expression is associated with development 
      of neurofibrillary tangles and neuron loss in P301L mice with motor and 
      behavioral deficits were identified. The data suggest that a major mechanism 
      underlying P301LTau neurodegeneration primarily involved altered expression of 
      genes contributing to inhibition of apoptosis and intracellular transport. We 
      propose that the expression of mutated P301L may lead to select altered 
      expression of genes which may cause neurodegeneration in FTDP-17.
FAU - Ho, L
AU  - Ho L
AD  - Neuroinflammation Research Center of the Department of Psychiatry, Mount Sinai 
      School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
FAU - Xiang, Z
AU  - Xiang Z
FAU - Mukherjee, P
AU  - Mukherjee P
FAU - Zhang, W
AU  - Zhang W
FAU - De Jesus, N
AU  - De Jesus N
FAU - Mirjany, M
AU  - Mirjany M
FAU - Yemul, S
AU  - Yemul S
FAU - Pasinetti, G M
AU  - Pasinetti GM
LA  - eng
GR  - AG02219/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Brain Chemistry/*genetics
MH  - Down-Regulation/genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Microtubules/metabolism
MH  - Mutation/genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - tau Proteins/*biosynthesis/*genetics
EDAT- 2001/08/29 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/08/29 10:00
PHST- 2001/08/29 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/08/29 10:00 [entrez]
AID - S0304-3940(01)02044-4 [pii]
AID - 10.1016/s0304-3940(01)02044-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Sep 7;310(1):1-4. doi: 10.1016/s0304-3940(01)02044-4.