PMID- 11525535
OWN - NLM
STAT- MEDLINE
DCOM- 20011221
LR  - 20171118
IS  - 0890-5096 (Print)
IS  - 0890-5096 (Linking)
VI  - 15
IP  - 4
DP  - 2001 Jul
TI  - Characterization of renal parenchymal perfusion during experimental infrarenal 
      aortic clamping and declamping with enhanced thermodiffusion electrodes.
PG  - 447-56
AB  - Despite multiple previous experimental and clinical investigations, it has not 
      been fully clarified until now whether infrarenal aortic cross-clamping (IRAC) 
      induces a significant disturbance of renal parenchymal perfusion. Most renal 
      cortical flow data collected thus far have been heterogenous because of inherent 
      limitations of available measurement technology. The enhanced thermal diffusion 
      (TD) electrode is a newly developed and previously validated prototype device 
      that allows continuous quantification of parenchymal kidney perfusion after local 
      probe implantation. We monitored renal perfusion during experimental IRAC with TD 
      for the first time, thereby also evaluating the potential applicability of the 
      method in clinical aortic surgery. IRAC (20 min) followed by sudden declamping 
      was performed in pigs under general anesthesia (n = 14). Renal cortical blood 
      flow (RCBF) was continuously quantified by TD, total aortic flow (TABF) and renal 
      artery flow (RABF) were measured by ultrasonic flow probes, and parameters of 
      systemic circulation were determined by Swan-Ganz catheter. Our results showed 
      that kidney perfusion can be continuously quantified using TD electrodes during 
      experimental aortic surgery in a porcine model. IRAC does not lead to a 
      significant impairment of RCBF in young pigs as measured by TD. Renal perfusion 
      appears to be predominantly pressure driven. Consequently, abrubt aortic 
      declamping can bring about prolonged renal ischemia. Transfer of the TD method to 
      RCBF monitoring during clinical aortic surgery appears to be feasible and should 
      be investigated in selected cases.
FAU - Kraus, T
AU  - Kraus T
AD  - Department of Surgery, Section for Vascular Surgery, Ruprecht-Karls University of 
      Heidelberg, Germany. Thomas_Kraus@med.uni-heidelberg.de
FAU - Mehrabi, A
AU  - Mehrabi A
FAU - Angelescu, M
AU  - Angelescu M
FAU - Golling, M
AU  - Golling M
FAU - Allenberg, J R
AU  - Allenberg JR
FAU - Klar, E
AU  - Klar E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
SB  - IM
MH  - Animals
MH  - Aorta/*physiology/*surgery
MH  - Blood Pressure/physiology
MH  - Cardiac Output/physiology
MH  - Diffusion
MH  - *Electrodes
MH  - Heart Rate/physiology
MH  - Kidney/blood supply
MH  - Models, Animal
MH  - Perfusion/*instrumentation
MH  - Regional Blood Flow/physiology
MH  - Renal Artery/*physiology/*surgery
MH  - Renal Circulation/physiology
MH  - *Surgical Instruments
MH  - Swine
MH  - Time Factors
EDAT- 2001/08/30 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/30 10:00
PHST- 2001/08/30 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/30 10:00 [entrez]
AID - S0890-5096(07)60124-1 [pii]
AID - 10.1007/s100160010121 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2001 Jul;15(4):447-56. doi: 10.1007/s100160010121.