PMID- 11526406
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20071108
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 2
IP  - 9
DP  - 2001 Sep
TI  - Inducible IL-2 production by dendritic cells revealed by global gene expression 
      analysis.
PG  - 882-8
AB  - Dendritic cells (DCs) are strong activators of primary T cell responses. Their 
      priming ability is acquired upon encounter with maturation stimuli. To identify 
      the genes that are differentially expressed upon maturation induced by exposure 
      to Gram-negative bacteria, a kinetic study of DC gene expression was done with 
      microarrays representing 11,000 genes and ESTs (expressed sequence tags). 
      Approximately 3000 differentially expressed transcripts were identified. We found 
      that functional interleukin 2 (IL-2) mRNA, which gave rise to IL-2 production, 
      was transiently up-regulated at early time-points after bacterial encounter. In 
      contrast, macrophages did not produce IL-2 upon bacterial stimulation. Thus, IL-2 
      is an additional key cytokine that confers unique T cell stimulatory capacity to 
      DCs.
FAU - Granucci, F
AU  - Granucci F
AD  - University of Milano-Bicocca, Department of Biotechnology and Bioscience, Piazza 
      della Scienza 2, Milan, Italy.
FAU - Vizzardelli, C
AU  - Vizzardelli C
FAU - Pavelka, N
AU  - Pavelka N
FAU - Feau, S
AU  - Feau S
FAU - Persico, M
AU  - Persico M
FAU - Virzi, E
AU  - Virzi E
FAU - Rescigno, M
AU  - Rescigno M
FAU - Moro, G
AU  - Moro G
FAU - Ricciardi-Castagnoli, P
AU  - Ricciardi-Castagnoli P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Interleukin-2)
RN  - 0 (RNA, Messenger)
SB  - IM
CIN - Nat Immunol. 2001 Sep;2(9):830-1. PMID: 11526397
MH  - Animals
MH  - Bone Marrow/growth & development
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Gene Expression Profiling
MH  - Gram-Negative Bacteria/immunology
MH  - Interleukin-2/*biosynthesis/genetics/physiology
MH  - Kinetics
MH  - *Lymphocyte Activation
MH  - Lymphocyte Culture Test, Mixed
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Oligonucleotide Array Sequence Analysis
MH  - RNA, Messenger/biosynthesis
MH  - T-Lymphocytes/immunology
EDAT- 2001/08/30 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/08/30 10:00
PHST- 2001/08/30 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/08/30 10:00 [entrez]
AID - ni0901-882 [pii]
AID - 10.1038/ni0901-882 [doi]
PST - ppublish
SO  - Nat Immunol. 2001 Sep;2(9):882-8. doi: 10.1038/ni0901-882.