PMID- 11526995
OWN - NLM
STAT- MEDLINE
DCOM- 20011210
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 50
IP  - 2
DP  - 2001 Jul 15
TI  - Repeated intermittent administration of psychomotor stimulant drugs alters the 
      acquisition of Pavlovian approach behavior in rats: differential effects of 
      cocaine, d-amphetamine and 3,4- methylenedioxymethamphetamine ("Ecstasy").
PG  - 137-43
AB  - BACKGROUND: Psychomotor stimulant drugs can produce long-lasting changes in 
      neurochemistry and behavior after multiple doses. In particular, neuroadaptations 
      within corticolimbic brain structures that mediate incentive learning and 
      motivated behavior have been demonstrated after chronic exposure to cocaine, 
      d-amphetamine, and 3,4-methylenedioxymethamphetamine (MDMA). As stimulus-reward 
      learning is likely relevant to addictive behavior (i.e., augmented conditioned 
      reward and stimulus control of behavior), we have investigated whether prior 
      repeated administration of psychomotor stimulant drugs (of abuse, including 
      cocaine, d-amphetamine, or MDMA, would affect the acquisition of Pavlovian 
      approach behavior. METHODS: Water-deprived rats were tested for the acquisition 
      of Pavlovian approach behavior after 5 days treatment with cocaine (15-20 mg/kg 
      once or twice daily), d-amphetamine (2.5 mg/kg once or twice daily), or MDMA (2.5 
      mg/kg twice daily) followed by a 7-day, drug-free period. RESULTS: Prior repeated 
      treatment with cocaine or d-amphetamine produced a significant enhancement of 
      acquisition of Pavlovian approach behavior, indicating accelerated 
      stimulus-reward learning, whereas MDMA administration produced increased 
      inappropriate responding, indicating impulsivity. Abnormal drug-induced approach 
      behavior was found to persist throughout the testing period. CONCLUSIONS: These 
      studies demonstrate that psychomotor stimulant-induced sensitization can produce 
      long-term alterations in stimulus-reward learning and impulse control that may 
      contribute to the compulsive drug taking that typifies addiction.
FAU - Taylor, J R
AU  - Taylor JR
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, 
      Connecticut 06508-8068, USA.
FAU - Jentsch, J D
AU  - Jentsch JD
LA  - eng
GR  - DA11026/DA/NIDA NIH HHS/United States
GR  - DA11717/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Central Nervous System Stimulants)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Stimulants/administration & dosage/*pharmacology
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Conditioning, Classical/*drug effects
MH  - Dextroamphetamine/administration & dosage/*pharmacology
MH  - Impulsive Behavior/psychology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Psychomotor Performance/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2001/08/31 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/31 10:00
PHST- 2001/08/31 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/31 10:00 [entrez]
AID - S0006322301011064 [pii]
AID - 10.1016/s0006-3223(01)01106-4 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2001 Jul 15;50(2):137-43. doi: 10.1016/s0006-3223(01)01106-4.