PMID- 11531255
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20181113
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 85
IP  - 5
DP  - 2001 Sep 1
TI  - Frequent genomic imbalances suggest commonly altered tumour genes in human 
      hepatocarcinogenesis.
PG  - 697-704
AB  - Hepatocellular carcinoma (HCC) is one of the most frequent-occurring malignant 
      tumours worldwide, but molecular changes of tumour DNA, with the exception of 
      viral integrations and p53 mutations, are poorly understood. In order to search 
      for common macro-imbalances of genomic tumour DNA, 21 HCCs and 3 HCC-cell lines 
      were characterized by comparative genomic hybridization (CGH), subsequent 
      database analyses and in selected cases by fluorescence in situ hybridization 
      (FISH). Chromosomal subregions of 1q, 8q, 17q and 20q showed frequent gains of 
      genomic material, while losses were most prevalent in subregions of 4q, 6q, 13q 
      and 16q. Deleted regions encompass tumour suppressor genes, like RB-1 and the 
      cadherin gene cluster, some of them previously identified as potential target 
      genes in HCC development. Several potential growth- or transformation-promoting 
      genes located in chromosomal subregions showed frequent gains of genomic 
      material. The present study provides a basis for further genomic and expression 
      analyses in HCCs and in addition suggests chromosome 4q to carry a so far 
      unidentified tumour suppressor gene relevant for HCC development.
CI  - Copyright 2001 Cancer Research Campaign.
FAU - Niketeghad, F
AU  - Niketeghad F
AD  - Institute of Pathology, University of Cologne, Joseph Stelzmann Str. 9, Cologne, 
      D-50931, Germany.
FAU - Decker, H J
AU  - Decker HJ
FAU - Caselmann, W H
AU  - Caselmann WH
FAU - Lund, P
AU  - Lund P
FAU - Geissler, F
AU  - Geissler F
FAU - Dienes, H P
AU  - Dienes HP
FAU - Schirmacher, P
AU  - Schirmacher P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
SB  - IM
MH  - Carcinoma, Hepatocellular/*genetics
MH  - *Chromosome Deletion
MH  - Female
MH  - Genes, Tumor Suppressor/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Liver Neoplasms/*genetics
MH  - Male
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
PMC - PMC2364116
EDAT- 2001/09/05 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/09/05 10:00
PHST- 2001/09/05 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/09/05 10:00 [entrez]
AID - S0007092001919639 [pii]
AID - 10.1054/bjoc.2001.1963 [doi]
PST - ppublish
SO  - Br J Cancer. 2001 Sep 1;85(5):697-704. doi: 10.1054/bjoc.2001.1963.