PMID- 11532338
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 93
IP  - 1
DP  - 2001 Sep 10
TI  - Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B 
      (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF).
PG  - 56-63
AB  - Here we have studied the distribution of mRNA for tyrosine kinase B (trkB), the 
      high-affinity receptor for brain-derived neurotrophic factor (BDNF) amongst 
      serotonergic cell bodies of the raphe nuclei and their ascending projections into 
      the dorsal hippocampus in the rat brain. Previous studies have shown that BDNF 
      has got trophic action on serotonergic neurons. In the present study, we provide 
      evidence that serotonergic neurons express mRNA for the functional receptor of 
      BDNF, trkB. Intracerebro-ventricular (i.c.v.) injection of the 5-HT-specific 
      neurotoxin, 5,7-dihydroxytryptamine, which lesions serotonergic cell bodies in 
      the raphe nuclei as well as their ascending projections into the dorsal 
      hippocampus, caused a dramatic loss of trkB mRNA from serotonergic cell bodies of 
      the dorsal raphe nucleus. In contrast, there was no change in the abundance of 
      trkB mRNA within the dorsal hippocampus. These findings provide direct evidence 
      for the expression of trkB mRNA by serotonergic neurons and suggest distinct 
      mechanisms of action of BDNF upon serotonergic neurons at the levels of their 
      cell bodies and terminal projection sites.
FAU - Madhav, T R
AU  - Madhav TR
AD  - Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, 
      USA.
FAU - Pei, Q
AU  - Pei Q
FAU - Zetterstrom, T S
AU  - Zetterstrom TS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Agents)
RN  - 31363-74-3 (5,7-Dihydroxytryptamine)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - 5,7-Dihydroxytryptamine
MH  - Animals
MH  - Antibodies
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Denervation
MH  - Gene Expression/physiology
MH  - Hippocampus/cytology/physiology
MH  - Male
MH  - Neurons/*physiology
MH  - RNA, Messenger/analysis
MH  - Raphe Nuclei/*cytology/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*genetics/metabolism
MH  - Serotonin/analysis/immunology/*physiology
MH  - Serotonin Agents
EDAT- 2001/09/05 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/05 10:00
PHST- 2001/09/05 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/05 10:00 [entrez]
AID - S0169328X01001838 [pii]
AID - 10.1016/s0169-328x(01)00183-8 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2001 Sep 10;93(1):56-63. doi: 
      10.1016/s0169-328x(01)00183-8.