PMID- 11532547
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20220409
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 80
IP  - 1
DP  - 2001 Aug
TI  - Chemokines in patients with ischaemic heart disease and the effect of coronary 
      angioplasty.
PG  - 55-60
AB  - Percutaneous coronary transluminal angioplasty (PTCA) may release inflammatory 
      mediators such as chemokines. Monocyte chemoattractant protein-1 (MCP-1) and 
      eotaxin (EOX) are monocyte- and eosinophil-specific chemokines involved in the 
      inflammation and pathogenesis of coronary atherosclerosis. A total of 28 patients 
      undergoing elective PTCA, 20 coronary artery disease (CAD) patients undergoing 
      coronary angiography and 28 healthy controls were studied. In PTCA patients 
      before the procedure, MCP-1 plasma levels (441+/-64 pg/ml) were similar to those 
      of CAD patients (430+/-24 pg/ml), and significantly higher compared with controls 
      (145+/-17 pg/ml, P<0.01). MCP-1 rose significantly after 3 and 6 months following 
      PTCA (696+/-89 and 876+/-86 pg/ml, respectively, P<0.01 vs. before PTCA). EOX 
      plasma levels (155+/-14 pg/ml) were similar to those of CAD patients (157+/-14 
      pg/ml), but significantly higher compared with controls (83.2+/-10 pg/ml, 
      P<0.05). EOX rose significantly 24 h (273+/-41 pg/ml, P<0.05) but not 3 months 
      after PTCA (160+/-20 and 158+/-19 pg/ml, respectively). These findings indicate 
      that chemokine-induced monocyte- and eosinophil-specific chemoattraction is 
      stimulated in patients with coronary artery disease. MCP-1 levels remain 
      significantly elevated for at least 6 months following elective PTCA, suggesting 
      an inflammatory stimulation.
FAU - Economou, E
AU  - Economou E
AD  - Cardiology Unit, Athens University Medical School, Hippokration Hospital, 114 
      Vasillisis Sofias, 11528, Athens, Greece.
FAU - Tousoulis, D
AU  - Tousoulis D
FAU - Katinioti, A
AU  - Katinioti A
FAU - Stefanadis, C
AU  - Stefanadis C
FAU - Trikas, A
AU  - Trikas A
FAU - Pitsavos, C
AU  - Pitsavos C
FAU - Tentolouris, C
AU  - Tentolouris C
FAU - Toutouza, M G
AU  - Toutouza MG
FAU - Toutouzas, P
AU  - Toutouzas P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (CCL11 protein, human)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemotactic Factors, Eosinophil)
RN  - 0 (Cytokines)
SB  - IM
CIN - Int J Cardiol. 2001 Sep-Oct;80(2-3):107-8. PMID: 11578699
MH  - Angioplasty, Balloon, Coronary/*adverse effects
MH  - Case-Control Studies
MH  - Chemokine CCL11
MH  - Chemokine CCL2/*blood
MH  - *Chemokines, CC
MH  - Chemotactic Factors, Eosinophil/*blood
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/immunology/*therapy
MH  - Statistics, Nonparametric
MH  - Up-Regulation
EDAT- 2001/09/05 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/09/05 10:00
PHST- 2001/09/05 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/09/05 10:00 [entrez]
AID - S0167-5273(01)00454-5 [pii]
AID - 10.1016/s0167-5273(01)00454-5 [doi]
PST - ppublish
SO  - Int J Cardiol. 2001 Aug;80(1):55-60. doi: 10.1016/s0167-5273(01)00454-5.