PMID- 11532615
OWN - NLM
STAT- MEDLINE
DCOM- 20020122
LR  - 20190901
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 6
DP  - 2001 Sep 1
TI  - Contribution of HLA alleles in the regulation of antibody production in Lyme 
      disease.
PG  - B10-6
AB  - A small subset of patients infected with Borrelia burgdorferi (Bb) does not 
      produce Bb specific antibody. Our research provides additional evidence of a 
      genetic predisposition for seronegativity in some individuals with Lyme disease. 
      Because human leukocyte antigen (HLA) class II, a heterodimeric glycoprotein, 
      plays an essential role in the regulation of antibody production, we investigated 
      the difference in HLA genes between seropositive and seronegative patients with 
      Lyme disease (LD). Our results show that HLA-DR7 was associated with anti-Bb 
      antibody production. Nine out of the 22 seropositive LD patients (40.9%) had 
      HLA-DRB1*0701, *0703, *0704 (HLA-DR7); only 1 out of the 18 seronegative LD 
      patients (5.6%) had HLA-DR7 (odds ratio (OR)=11.8, P=0.0126). HLA-DRB1*01021 and 
      HLA-DRB1*0101, *0104, *0105 (HLA-DR1) contributed negatively to anti-Bb antibody 
      production. Seven of 18 seronegative LD patients had HLA-DR1, only 1 of 22 
      seropositive LD patients had HLA-DR1 (38.9% vs. 4.5%, OR=13.4, P=0.0138). These 
      results suggest that the presence and or lack of production of specific antibody 
      to Bb infection may be associated with particular HLA specificities of the Class 
      II.
FAU - Wang, P
AU  - Wang P
AD  - Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New 
      York, USA. ping1wang@hotmail.com
FAU - Hilton, E
AU  - Hilton E
LA  - eng
PT  - Journal Article
DEP - 20010901
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Bacterial/*blood
MH  - Borrelia burgdorferi/*immunology
MH  - DNA/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Lyme Disease/blood/*genetics/microbiology
MH  - Male
MH  - Middle Aged
EDAT- 2001/09/05 10:00
MHDA- 2002/01/23 10:01
CRDT- 2001/09/05 10:00
PHST- 2001/09/05 10:00 [pubmed]
PHST- 2002/01/23 10:01 [medline]
PHST- 2001/09/05 10:00 [entrez]
AID - 10.2741/wang [doi]
PST - epublish
SO  - Front Biosci. 2001 Sep 1;6:B10-6. doi: 10.2741/wang.