PMID- 11535234
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20221207
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 189
IP  - 1-2
DP  - 2001 Aug 15
TI  - Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis.
PG  - 59-64
AB  - The aim of this study was to elucidate the roles of human leukocyte antigen (HLA) 
      class II genes in disease susceptibility in Japanese adult patients with 
      myasthenia gravis (MG). A number of studies have shown that MG is correlated with 
      DR3 in Caucasians. In Japanese, infantile MG is associated with DR9, but the HLA 
      class II alleles associated with adult MG remains unclear. HLA-DRB1 and DQB1 
      alleles were determined by genotyping in 75 Japanese adult patients with MG and 
      in 115 race-matched healthy adults. No statistically significant difference was 
      observed in the overall prevalences of DRB1 and DQB1 alleles between MG patients 
      and healthy controls, even when the patients and controls were stratified on the 
      basis of their gender. MG patients with DQB1*0604 were younger and those with 
      DQB1*0402 were older at disease onset than those without (P=0.03 and 0.008, 
      respectively). Concomitant autoimmune thyroid disease was associated with 
      DRB1*0803 (P=0.0009, corrected P=0.04). In addition, anti-acetylcholine receptor 
      antibody levels were significantly higher in patients with DQB1*0604 than in 
      those without (P=0.045). These findings indicate that immunogenetic backgrounds 
      in Japanese adult MG patients are heterogeneous and are apparently different from 
      those in Caucasian patients.
FAU - Suzuki, S
AU  - Suzuki S
AD  - Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku, Tokyo 160-8582, Japan.
FAU - Kuwana, M
AU  - Kuwana M
FAU - Yasuoka, H
AU  - Yasuoka H
FAU - Tanaka, K
AU  - Tanaka K
FAU - Fukuuchi, Y
AU  - Fukuuchi Y
FAU - Kawakami, Y
AU  - Kawakami Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Asian People/*genetics
MH  - Autoimmune Diseases/*ethnology/genetics/immunology
MH  - Comorbidity
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Myasthenia Gravis/*ethnology/genetics/immunology
MH  - Thyroiditis, Autoimmune/epidemiology
MH  - White People/genetics
EDAT- 2001/09/06 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/06 10:00
PHST- 2001/09/06 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/06 10:00 [entrez]
AID - S0022510X01005603 [pii]
AID - 10.1016/s0022-510x(01)00560-3 [doi]
PST - ppublish
SO  - J Neurol Sci. 2001 Aug 15;189(1-2):59-64. doi: 10.1016/s0022-510x(01)00560-3.