PMID- 11536158
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20191105
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 31
IP  - 9
DP  - 2001 Sep
TI  - Differential migration of in vivo primed B and T lymphocytes to lymphoid and 
      non-lymphoid organs.
PG  - 2603-11
AB  - Our study describes tissue-specific migration of T and B cells during a localized 
      anti-viral immune response. After mouse mammary tumor virus (MMTV) injection, B 
      lymphocytes of the draining lymph node become infected and present a retroviral 
      superantigen to CD4(+) T lymphocytes. Infected B cells receive 
      superantigen-mediated help in a fashion comparable to classical immune responses. 
      To investigate the fate of T and B lymphocytes that had interacted via cognate 
      help in the same peripheral lymph node microenvironment we adoptively transferred 
      them into naive recipients. Here we show that MMTV-infected B cells and 
      superantigen-stimulated T cells were programmed to migrate to distinct sites of 
      the body. Plasmablasts but not T cells migrated to the mammary gland and 
      activated alpha4beta1 integrins were found to have a crucial role in the 
      migration to the mammary gland. In contrast, T cells had a much higher affinity 
      for secondary lymphoid organs and large intestine. This demonstrates that upon 
      antigen-driven B and T lymphocyte interaction in the local draining lymph node a 
      subset-specific homing program for B and T lymphocytes is induced.
FAU - Finke, D
AU  - Finke D
AD  - Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 
      Epalinges, Switzerland.
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, Viral)
RN  - 0 (Integrin alpha4beta1)
RN  - 0 (Integrins)
RN  - 0 (Receptors, Lymphocyte Homing)
RN  - 0 (Superantigens)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Antigens, Viral/immunology
MH  - B-Lymphocytes/*immunology/transplantation
MH  - Breast/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology/transplantation
MH  - *Cell Movement
MH  - Female
MH  - Integrin alpha4beta1
MH  - Integrins/physiology
MH  - Lymphocyte Activation
MH  - Lymphoid Tissue/*immunology
MH  - Mammary Tumor Virus, Mouse/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Receptors, Lymphocyte Homing/physiology
MH  - Retroviridae Infections/immunology
MH  - Superantigens/immunology
MH  - Vascular Cell Adhesion Molecule-1/metabolism
EDAT- 2001/09/06 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/09/06 10:00
PHST- 2001/09/06 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/09/06 10:00 [entrez]
AID - 10.1002/1521-4141(200109)31:9<2603::AID-IMMU2603>3.0.CO;2-8 [pii]
AID - 10.1002/1521-4141(200109)31:9&#60;2603::aid-immu2603&#62;3.0.co;2-8 [doi]
PST - ppublish
SO  - Eur J Immunol. 2001 Sep;31(9):2603-11. doi: 
      10.1002/1521-4141(200109)31:9&#60;2603::aid-immu2603&#62;3.0.co;2-8.