PMID- 11543891 OWN - NLM STAT- MEDLINE DCOM- 20010927 LR - 20190906 IS - 0198-8859 (Print) IS - 0198-8859 (Linking) VI - 62 IP - 9 DP - 2001 Sep TI - The origin of Palestinians and their genetic relatedness with other Mediterranean populations. PG - 889-900 AB - The genetic profile of Palestinians has, for the first time, been studied by using human leukocyte antigen (HLA) gene variability and haplotypes. The comparison with other Mediterranean populations by using neighbor-joining dendrograms and correspondence analyses reveal that Palestinians are genetically very close to Jews and other Middle East populations, including Turks (Anatolians), Lebanese, Egyptians, Armenians, and Iranians. Archaeologic and genetic data support that both Jews and Palestinians came from the ancient Canaanites, who extensively mixed with Egyptians, Mesopotamian, and Anatolian peoples in ancient times. Thus, Palestinian-Jewish rivalry is based in cultural and religious, but not in genetic, differences. The relatively close relatedness of both Jews and Palestinians to western Mediterranean populations reflects the continuous circum-Mediterranean cultural and gene flow that have occurred in prehistoric and historic times. This flow overtly contradicts the demic diffusion model of western Mediterranean populations substitution by agriculturalists coming from the Middle East in the Mesolithic-Neolithic transition. FAU - Arnaiz-Villena, A AU - Arnaiz-Villena A AD - Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es FAU - Elaiwa, N AU - Elaiwa N FAU - Silvera, C AU - Silvera C FAU - Rostom, A AU - Rostom A FAU - Moscoso, J AU - Moscoso J FAU - Gomez-Casado, E AU - Gomez-Casado E FAU - Allende, L AU - Allende L FAU - Varela, P AU - Varela P FAU - Martinez-Laso, J AU - Martinez-Laso J LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Retracted Publication PL - United States TA - Hum Immunol JT - Human immunology JID - 8010936 RN - 0 (HLA Antigens) RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQB1 antigen) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) SB - IM RIN - Suciu-Foca N, Lewis R. Hum Immunol. 2001 Oct;62(10):1063. PMID: 11600210 CIN - Hum Immunol. 2001 Oct;62(10):1064. PMID: 11600211 MH - Alleles MH - Arabs/genetics MH - Gene Frequency MH - Greece/ethnology MH - HLA Antigens/*genetics MH - HLA-A Antigens/genetics MH - HLA-B Antigens/genetics MH - HLA-DQ Antigens MH - HLA-DQ beta-Chains MH - HLA-DR Antigens/genetics MH - HLA-DRB1 Chains MH - Haplotypes/genetics MH - Humans MH - Islam MH - Israel MH - Jews/genetics MH - Linkage Disequilibrium MH - Mediterranean Region MH - Middle East MH - Phylogeny MH - Polymorphism, Genetic/genetics EDAT- 2001/09/07 10:00 MHDA- 2001/09/28 10:01 CRDT- 2001/09/07 10:00 PHST- 2001/09/07 10:00 [pubmed] PHST- 2001/09/28 10:01 [medline] PHST- 2001/09/07 10:00 [entrez] AID - S0198885901002889 [pii] AID - 10.1016/s0198-8859(01)00288-9 [doi] PST - ppublish SO - Hum Immunol. 2001 Sep;62(9):889-900. doi: 10.1016/s0198-8859(01)00288-9.