PMID- 11543896
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 62
IP  - 9
DP  - 2001 Sep
TI  - African diversity from the HLA point of view: influence of genetic drift, 
      geography, linguistics, and natural selection.
PG  - 937-48
AB  - This study investigates the influence of different evolutionary factors on the 
      patterns of human leukocyte antigen (HLA) genetic diversity within sub-Saharan 
      Africa, and between Africa, Europe, and East Asia. This is done by comparing the 
      significance of several statistics computed on equivalent population data sets 
      tested for two HLA class II loci, DRB1 and DPB1, which strongly differ from each 
      other by the shape of their allelic distributions. Similar results are found for 
      the two loci concerning highly significant correlations between geographic and 
      genetic distances at the world scale, high levels of genetic diversity within 
      sub-Saharan Africa and East Asia, and low within Europe, and low genetic 
      differentiations among the three broad continental areas, with no special 
      divergence of Africa. On the other hand, DPB1 behaves as a neutral polymorphism, 
      although a significant excess of heterozygotes is often observed for DRB1. 
      Whereas the pattern observed for DPB1 is explained by geographic differentiations 
      and genetic drift in isolated populations, balancing selection is likely to have 
      prevented genetic differentiations among populations at the DRB1 locus. However, 
      this selective effect did not disrupt the high correlation found between DRB1 and 
      geography at the world scale, nor between DRB1 and linguistic differentiations at 
      the African level.
FAU - Sanchez-Mazas, A
AU  - Sanchez-Mazas A
AD  - Laboratory of Genetics and Biometry, Department of Anthropology and Ecology, 
      University of Geneva, Geneva, Switzerland. alicia.sanchez-mazas@anthro.unige.ch
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin Gm Allotypes)
RN  - 0 (Rh-Hr Blood-Group System)
SB  - IM
MH  - Africa South of the Sahara
MH  - Africa, Northern
MH  - Alleles
MH  - Black People/*genetics
MH  - Cluster Analysis
MH  - Europe
MH  - Asia, Eastern
MH  - Gene Frequency/*genetics
MH  - HLA-D Antigens/*genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Humans
MH  - Immunoglobulin Gm Allotypes/genetics
MH  - *Linguistics
MH  - Rh-Hr Blood-Group System/genetics
MH  - *Selection, Genetic
EDAT- 2001/09/07 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/09/07 10:00
PHST- 2001/09/07 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/09/07 10:00 [entrez]
AID - S0198-8859(01)00293-2 [pii]
AID - 10.1016/s0198-8859(01)00293-2 [doi]
PST - ppublish
SO  - Hum Immunol. 2001 Sep;62(9):937-48. doi: 10.1016/s0198-8859(01)00293-2.