PMID- 11544565
OWN - NLM
STAT- MEDLINE
DCOM- 20011205
LR  - 20131121
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 33
IP  - 8
DP  - 2001 Aug
TI  - Primary hyperparathyroidism in patients with multiple endocrine neoplasia type 1: 
      comparison with sporadic parathyroid adenomas.
PG  - 499-503
AB  - A prospective study on the natural course of primary hyperparathyroidism has 
      recently been reported. Since hyperparathyroidism in multiple endocrine neoplasia 
      type 1 (MEN 1) is genetically distinct from most forms of sporadic 
      hyperparathyroidism, it is important to know the natural course of 
      hyperparathyroidism in MEN 1 for better clinical management. For this purpose, we 
      retrospectively reviewed clinical parameters of patients with MEN 1 when they 
      were diagnosed as having hyperparathyroidism, and compared them with those of 
      patients with sporadic primary hyperparathyroidism. In patients with MEN 1: 1) 
      levels of intact PTH (i-PTH) gradually increased with age, which accelerated over 
      40 years; 2) compared to the steep rise in i-PTH levels in aged patients, 
      increase in serum calcium or decrease of serum inorganic phosphate concentration 
      was relatively mild, and 3) the high concentrations of i-PTH in aged patients 
      were not due to renal insufficiency. These features were not observed in patients 
      with sporadic primary parathyroid adenomas. Clinical features of untreated 
      hyperparathyroidism in MEN 1 may be significantly affected by the age of the 
      patient. The effect, if any, of age-dependent deterioration on recurrence rate 
      after subtotal or total parathyroidectomy requires further elucidation.
FAU - Katai, M
AU  - Katai M
AD  - Department of Aging Medicine and Geriatrics, Shinshu University School of 
      Medicine, 3-1-1 Asahi, Matsumoto, 390-8621 Japan.
FAU - Sakurai, A
AU  - Sakurai A
FAU - Ikeo, Y
AU  - Ikeo Y
FAU - Hashizume, K
AU  - Hashizume K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adenoma/blood
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*blood
MH  - Calcium/blood
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/*blood/complications/pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*blood/complications/genetics
MH  - Organ Size
MH  - Parathyroid Glands/pathology
MH  - Parathyroid Hormone/*blood
MH  - Parathyroid Neoplasms/*blood/pathology
MH  - Phosphates/blood
MH  - Regression Analysis
MH  - Renal Insufficiency/blood
MH  - Retrospective Studies
EDAT- 2001/09/07 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/07 10:00
PHST- 2001/09/07 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/07 10:00 [entrez]
AID - 10.1055/s-2001-16944 [doi]
PST - ppublish
SO  - Horm Metab Res. 2001 Aug;33(8):499-503. doi: 10.1055/s-2001-16944.