PMID- 11549218
OWN - NLM
STAT- MEDLINE
DCOM- 20020128
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 156
IP  - 2-3
DP  - 2001 Jul
TI  - Effects of phencyclidine on prepulse inhibition of acoustic startle response in 
      the macaque.
PG  - 165-8
AB  - RATIONALE: Prepulse inhibition (PPI) of the acoustic startle response (ASR) 
      provides an index of neurophysiological dysfunction in schizophrenia and a method 
      for analyzing underlying neurochemical mechanisms. In rodents, phencyclidine 
      (PCP) and other N-methyl-D-aspartate receptor (NMDAR) antagonists induce 
      schizophrenia-like PPI deficits. Similar effects have recently been observed in a 
      New World monkey species, Cebus apella. OBJECTIVES: The present study evaluates 
      the degree to which similar effects are observed in an Old World monkey, M. 
      fascicularis. METHODS: An initial study evaluated effects of interstimulus 
      interval on PPI amplitude and latency. A subsequent study evaluated effects of 
      PCP (0.25 mg/kg i.m.) on PPI of the ASR. RESULTS: Prepulses reduced both the 
      amplitude and latency of the ASR. PCP treatment prevented both effects without 
      affecting amplitude or latency of the ASR itself. CONCLUSIONS: These results 
      demonstrate that both amplitude reduction and latency facilitation are observed 
      during PPI in the monkey and are disrupted by PCP.
FAU - Javitt, D C
AU  - Javitt DC
AD  - Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute, 
      Orangeburg, NY 10962, USA. javitt@nki.rfmh.org
FAU - Lindsley, R W
AU  - Lindsley RW
LA  - eng
GR  - K02 MH01439/MH/NIMH NIH HHS/United States
GR  - R01 DA03383/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Electromyography
MH  - Evoked Potentials/drug effects
MH  - Hallucinogens/*pharmacology
MH  - Macaca fascicularis
MH  - Phencyclidine/*pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
MH  - Reflex, Startle/*drug effects
EDAT- 2001/09/11 10:00
MHDA- 2002/01/29 10:01
CRDT- 2001/09/11 10:00
PHST- 2001/09/11 10:00 [pubmed]
PHST- 2002/01/29 10:01 [medline]
PHST- 2001/09/11 10:00 [entrez]
AID - 10.1007/s002130100758 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2001 Jul;156(2-3):165-8. doi: 10.1007/s002130100758.