PMID- 11549801
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20171101
IS  - 1018-8665 (Print)
IS  - 1018-8665 (Linking)
VI  - 203
IP  - 1
DP  - 2001
TI  - Detection of HTLV-I proviral DNA in sarcoidosis.
PG  - 53-6
AB  - 'Sarcoidosis-lymphoma syndrome' is known as an association of sarcoidosis with 
      malignant lymphoma. We report a 56-year-old woman with systemic sarcoidosis who 
      was seropositive for antibody against human T cell lymphoma/leukemia virus type I 
      (HTLV-I). This patient showed integration of HTLV-I proviral DNA within cutaneous 
      sarcoid nodules, but not in peripheral blood mononuclear cells. Neither atypical 
      lymphocytes nor a T cell receptor beta1 gene rearrangement were observed in 
      peripheral blood mononuclear cells or in cutaneous nodules, indicating that the 
      patient did not have a smouldering type of adult T cell lymphoma/leukemia. 
      Detection of integration of HTLV-I proviral DNA in cutaneous sarcoid nodules 
      could suggest that the sarcoid nodules might have been generated as a protective 
      response to chronic stimuli of HTLV-I.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Yajima, A
AU  - Yajima A
AD  - Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
FAU - Kawada, A
AU  - Kawada A
FAU - Aragane, Y
AU  - Aragane Y
FAU - Tezuka, T
AU  - Tezuka T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/*analysis
MH  - Female
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/complications/diagnosis/*virology
MH  - Middle Aged
MH  - Proviruses/*genetics/isolation & purification
MH  - Sarcoidosis/complications/pathology/*virology
MH  - Skin/pathology/*virology
MH  - *Virus Integration
EDAT- 2001/09/11 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/09/11 10:00
PHST- 2001/09/11 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/09/11 10:00 [entrez]
AID - 51704 [pii]
AID - 10.1159/000051704 [doi]
PST - ppublish
SO  - Dermatology. 2001;203(1):53-6. doi: 10.1159/000051704.