PMID- 11550277
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20191025
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 32
IP  - 2
DP  - 2001 Oct
TI  - Chronic myelogenous leukemia: laboratory diagnosis and monitoring.
PG  - 97-111
AB  - Rapid developments have occurred both in laboratory medicine and in therapeutic 
      interventions for the management of patients with chronic myelogenous leukemia 
      (CML). With a wide array of laboratory tests available, selecting the appropriate 
      test for a specific diagnostic or therapeutic setting has become increasingly 
      difficult. In this review, we first discuss, from the point of view of laboratory 
      medicine, the advantages and disadvantages of several commonly used laboratory 
      assays, including cytogenetics, fluorescence in situ hybridization (FISH), and 
      qualitative and quantitative reverse transcriptase-polymerase chain reaction 
      (RT-PCR). We then discuss, from the point of view of clinical care, the test(s) 
      of choice for the most common clinical scenarios, including diagnosis and 
      monitoring of the therapeutic response and minimal residual disease in patients 
      treated with different therapies. The purpose of this review is to help 
      clinicians and laboratory physicians select appropriate tests for the diagnosis 
      and monitoring of CML, with the ultimate goal of improving the cost-effective 
      usage of clinical laboratories and improving patient care.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Wang, Y L
AU  - Wang YL
AD  - Department of Pathology and Laboratory Medicine, Hospital of the University of 
      Pennsylvania, 413b Stellar-Chance Building, 422 Curie Blvd., Philadelphia, PA 
      19104, USA.
FAU - Bagg, A
AU  - Bagg A
FAU - Pear, W
AU  - Pear W
FAU - Nowell, P C
AU  - Nowell PC
FAU - Hess, J L
AU  - Hess JL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Cytogenetic Analysis/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*diagnosis/drug 
      therapy/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
RF  - 119
EDAT- 2001/09/11 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/11 10:00
PHST- 2001/09/11 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/11 10:00 [entrez]
AID - 10.1002/gcc.1171 [pii]
AID - 10.1002/gcc.1171 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2001 Oct;32(2):97-111. doi: 10.1002/gcc.1171.