PMID- 11550823
OWN - NLM
STAT- MEDLINE
DCOM- 20020123
LR  - 20191210
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 25
IP  - 6
DP  - 2001 Sep
TI  - Evaluation of Roche Abuscreen ONLINE amphetamine immunoassay for screening of new 
      amphetamine analogues.
PG  - 471-5
AB  - Some structural analogues of amphetamine are now important drugs of abuse in 
      Thailand. The utility of the Roche Abuscreen ONLINE reagent amphetamine 
      immunoassay test kit to detect these analogues was studied. The test showed high 
      cross-reactivity to 3,4-methylenedioxyamphetamine (MDA), but low cross-reactivity 
      to its parent drugs, 3,4-methylenedioxymethamphetamine (MDMA) and 
      3,4-methylenedioxyethylamphetamine (MDEA), as well as to methamphetamine and 
      ethylamphetamine. Also observed in this study was a methamphetamine detection 
      sensitivity enhancement effect of amphetamine, which is the active metabolite of 
      methamphetamine. Correlation between the measured concentration values and the 
      actual amount of these two drugs in the sample was, however, low. Thus, the test 
      can be used to detect methamphetamine only when amphetamine is also present in 
      the sample resulting from either co-administration or metabolism of 
      methamphetamine.
FAU - Lekskulchai, V
AU  - Lekskulchai V
AD  - Department of Pathology, Faculty of Medicine, Srinakharinwirot University, 
      Bangkok, Thailand.
FAU - Mokkhavesa, C
AU  - Mokkhavesa C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/*diagnosis
MH  - Amphetamines/*analysis
MH  - Central Nervous System Stimulants/*analysis
MH  - Humans
MH  - Immunoassay/*methods
MH  - Methamphetamine/*analysis
MH  - Sensitivity and Specificity
EDAT- 2001/09/12 10:00
MHDA- 2002/01/24 10:01
CRDT- 2001/09/12 10:00
PHST- 2001/09/12 10:00 [pubmed]
PHST- 2002/01/24 10:01 [medline]
PHST- 2001/09/12 10:00 [entrez]
AID - 10.1093/jat/25.6.471 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2001 Sep;25(6):471-5. doi: 10.1093/jat/25.6.471.