PMID- 11553308
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 14
IP  - 3
DP  - 2001 Aug
TI  - Double-pulse transcranial magnetic stimulation over the frontal eye field 
      facilitates triggering of memory-guided saccades.
PG  - 571-5
AB  - The study investigated the influence of double-pulse transcranial magnetic 
      stimulation (dTMS) on memory-guided saccade triggering. Double pulses with 
      interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right 
      frontal eye field (FEF) and as control over the occipital cortex. A significant 
      dTMS effect was found exclusively for contralateral saccades; latency of 
      memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms 
      compared to latency without stimulation. This effect proved to be specific for 
      the ISI of 50 ms over the FEF because control stimulation with the same ISI over 
      the occipital cortex had no significant effect on latency of memory-guided 
      saccades. The results of our study showed that, by using an appropriate ISI, dTMS 
      is able to facilitate contralateral saccade triggering by stimulating the FEF. 
      This suggests that TMS interferes specifically with saccade triggering 
      mechanisms, probably by acting on presaccadic neurons of the FEF.
FAU - Wipfli, M
AU  - Wipfli M
AD  - Eye Movement Research Laboratory, Department of Neurology, University of Bern, 
      Inselspital, CH-3010 Bern, Switzerland.
FAU - Felblinger, J
AU  - Felblinger J
FAU - Mosimann, U P
AU  - Mosimann UP
FAU - Hess, C W
AU  - Hess CW
FAU - Schlaepfer, T E
AU  - Schlaepfer TE
FAU - Muri, R M
AU  - Muri RM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - *Electromagnetic Fields
MH  - Electrooculography
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Male
MH  - Memory/*physiology
MH  - Occipital Lobe/physiology
MH  - Saccades/*physiology
MH  - Visual Cortex/*physiology
MH  - Visual Fields/*physiology
EDAT- 2001/09/13 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/09/13 10:00
PHST- 2001/09/13 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/09/13 10:00 [entrez]
AID - ejn1671 [pii]
AID - 10.1046/j.0953-816x.2001.01671.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2001 Aug;14(3):571-5. doi: 10.1046/j.0953-816x.2001.01671.x.