PMID- 11554446
OWN - NLM
STAT- MEDLINE
DCOM- 20020305
LR  - 20231213
IS  - 1523-0864 (Print)
IS  - 1523-0864 (Linking)
VI  - 3
IP  - 4
DP  - 2001 Aug
TI  - Metal response element (MRE)-binding transcription factor-1 (MTF-1): structure, 
      function, and regulation.
PG  - 577-96
AB  - Metal-responsive control of the expression of genes involved in metal metabolism 
      and metal homeostasis allows an organism to tightly regulate the free or 
      bioavailable concentration of beneficial metal ions, such as zinc, copper, and 
      iron, within an acceptable range, while efficiently removing nonbeneficial or 
      toxic metals. Emerging evidence also suggests that metal homeostasis is 
      intimately coupled to the oxidative stress response in many cell types. The 
      expression of genes that encode metallothioneins in all vertebrate cells is 
      strongly induced by potentially toxic concentrations of zinc and cadmium, as well 
      as in response to strong oxidizing agents, including hydrogen peroxide. This 
      induction requires a cis-acting DNA element, termed a metal response element 
      (MRE), and MRE-binding transcription factor-1 (MTF-1), a Cys2-His2 zinc finger 
      protein. This review summarizes recent progress that has been made toward 
      understanding the structure, function, and metalloregulation of mammalian MTF-1.
FAU - Giedroc, D P
AU  - Giedroc DP
AD  - Center for Advanced Biomolecular Research, Department of Biochemistry and 
      Biophysics, Texas A&M University, College Station 77843-2128, USA.
FAU - Chen, X
AU  - Chen X
FAU - Apuy, J L
AU  - Apuy JL
LA  - eng
GR  - GM42569/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Metals)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
RN  - 9038-94-2 (Metallothionein)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Allosteric Regulation
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Biological Availability
MH  - DNA/metabolism
MH  - DNA-Binding Proteins
MH  - Drosophila Proteins/chemistry/genetics
MH  - Homeostasis
MH  - Humans
MH  - Metallothionein/genetics/physiology
MH  - Metals/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Conformation
MH  - Saccharomyces cerevisiae Proteins/chemistry/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Structure-Activity Relationship
MH  - Takifugu/genetics
MH  - Transcription Factors/*chemistry/physiology
MH  - Transcription, Genetic/*physiology
MH  - Zinc/chemistry/physiology
MH  - Transcription Factor MTF-1
RF  - 77
EDAT- 2001/09/14 10:00
MHDA- 2002/03/07 10:01
CRDT- 2001/09/14 10:00
PHST- 2001/09/14 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2001/09/14 10:00 [entrez]
AID - 10.1089/15230860152542943 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2001 Aug;3(4):577-96. doi: 10.1089/15230860152542943.